LC-MS determination of Nicotiana benthamiana host plant proteins in the drug products of recombinant plant-produced pembrolizumab
Abstract Host proteins from Nicotiana benthamiana can remain in the recombinant biologic products after undergoing multiple steps of purification. These plant protein impurities may induce immunogenicity upon use. Therefore, controlling and monitoring host cell proteins is necessary throughout the p...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-11541-6 |
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