Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study)
Introduction: Premature coronary artery disease (PCAD) has an ascending trend especially in developing countries. This study have investigated the risk factors and severity of developing CAD across various Iranian ethnicities. Methods: This case-control study was done on 3015 Iranian patients underg...
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Tabriz University of Medical Sciences
2025-03-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-49.pdf |
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| author | Seyed Ali Moezi Bady Fatemeh Salmani Ehsan Zarepur Toba Kazemi Neda Partovi Nazanin Hanafi Bojd Saeede Khosravi Bizhaem Alireza Khosravi Farsani Noushin Mohammadifard Fereidoon Nouhi Hassan Alikhasi Masoumeh Sadeghi Hamidreza Roohafza Razieh Hassannejad Katayoun Rabiei Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Habib Haybar Reza Madadi Nahid Azdaki Nizal Sarrafzadegan |
| author_facet | Seyed Ali Moezi Bady Fatemeh Salmani Ehsan Zarepur Toba Kazemi Neda Partovi Nazanin Hanafi Bojd Saeede Khosravi Bizhaem Alireza Khosravi Farsani Noushin Mohammadifard Fereidoon Nouhi Hassan Alikhasi Masoumeh Sadeghi Hamidreza Roohafza Razieh Hassannejad Katayoun Rabiei Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Habib Haybar Reza Madadi Nahid Azdaki Nizal Sarrafzadegan |
| author_sort | Seyed Ali Moezi Bady |
| collection | DOAJ |
| description | Introduction: Premature coronary artery disease (PCAD) has an ascending trend especially in developing countries. This study have investigated the risk factors and severity of developing CAD across various Iranian ethnicities. Methods: This case-control study was done on 3015 Iranian patients undergoing coronary artery angiography, across highly populated Iranian ethnicities including Bakhtiari, Azari, Qashqai, Arab, Fars, Kurd, Gilak, and Lur. This study was performed over three years in 14 capitals of provinces in Iran headed by Isfahan Cardiovascular Research Center, by including men≤60 years old and women≤70 years undergoing coronary artery angiography. If they had coronary stenosis above 75% (more than 50% in the left main), they were categorized as Case group .The effects of conventional risk factors as well as psychosocial ones including age, gender, weight, Body mass index (BMI), economic status, cigarette smoking, drugs of abuse, stress, anxiety, diabetes, hypertension, etc. were determined in each ethnicity using decision tree statistical method. Also, via logistic regression method, the odds of incidence of CAD in each ethnicity were specified against the Fars ethnicity (the predominant ethnicity in Iran). Results: The most common risk factor among different ethnicities was age and male gender. Also, among the Iranian ethnicities, Kurd had the lowest chance while Gilak and Azari had the highest chance of developing PCAD as compared to the Fars ethnicity. Investigation of the behavioral and psychological dimensions indicated that stress was significantly higher among those without coronary artery involvement as compared to those with this involvement. The decision tree model could predict that among Gilakis, Fasting blood sugar (FBS) above 126 and in Lurs opium as well as diastolic blood pressure above 85, and in Kurds male gender would considerably increase the odds of developing CAD. Conclusion: The model obtained from the decision tree indicated that although variables of age, gender, cigarette, and opium are among the main risk factors for involvement of coronary arteries among young adult patients, in different ethnicities, the risk level of each of these risk factors in incidence of PCAD is different. This means among Kurds, age, among Gilakis diabetes, and among Lurs opium are more important. |
| format | Article |
| id | doaj-art-0cde77f7a1a149a7a127ef20a0c94120 |
| institution | OA Journals |
| issn | 2008-5117 2008-6830 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Tabriz University of Medical Sciences |
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| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj-art-0cde77f7a1a149a7a127ef20a0c941202025-08-20T02:16:03ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302025-03-01171495710.34172/jcvtr.025.33190jcvtr-33190Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study)Seyed Ali Moezi Bady0Fatemeh Salmani1Ehsan Zarepur2Toba Kazemi3Neda Partovi4Nazanin Hanafi Bojd5Saeede Khosravi Bizhaem6Alireza Khosravi Farsani7Noushin Mohammadifard8Fereidoon Nouhi9Hassan Alikhasi10Masoumeh Sadeghi11Hamidreza Roohafza12Razieh Hassannejad13Katayoun Rabiei14Nahid Salehi15Kamal Solati16Masoud Lotfizadeh17Samad Ghaffari18Elmira Javanmardi19Arsalan Salari20Mostafa Dehghani21Mostafa Cheraghi22Habib Haybar23Reza Madadi24Nahid Azdaki25Nizal Sarrafzadegan26Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranGeriatric Health Research Center, Birjand University of Medical Sciences, Birjand, IranInterventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranHypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranPediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranThe Iranian Network of Cardiovascular Research (INCVR), IranHeart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranIsfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranPediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranCardiovascular Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, IranSocial Determinants of Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, IranThe Iranian Network of Cardiovascular Research (INCVR), IranDepartment of Cardiovascular Medicine, Heart Center, Maragheh University of Medical Sciences, Amiralmomenin Hospital, Maragheh, IranDepartment of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, IranDepartment of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, IranThe Iranian Network of Cardiovascular Research (INCVR), IranDepartment of Cardiology, Zanjan University of Medical Sciences, Zanjan, IranCardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, IranThe Iranian Network of Cardiovascular Research (INCVR), IranIntroduction: Premature coronary artery disease (PCAD) has an ascending trend especially in developing countries. This study have investigated the risk factors and severity of developing CAD across various Iranian ethnicities. Methods: This case-control study was done on 3015 Iranian patients undergoing coronary artery angiography, across highly populated Iranian ethnicities including Bakhtiari, Azari, Qashqai, Arab, Fars, Kurd, Gilak, and Lur. This study was performed over three years in 14 capitals of provinces in Iran headed by Isfahan Cardiovascular Research Center, by including men≤60 years old and women≤70 years undergoing coronary artery angiography. If they had coronary stenosis above 75% (more than 50% in the left main), they were categorized as Case group .The effects of conventional risk factors as well as psychosocial ones including age, gender, weight, Body mass index (BMI), economic status, cigarette smoking, drugs of abuse, stress, anxiety, diabetes, hypertension, etc. were determined in each ethnicity using decision tree statistical method. Also, via logistic regression method, the odds of incidence of CAD in each ethnicity were specified against the Fars ethnicity (the predominant ethnicity in Iran). Results: The most common risk factor among different ethnicities was age and male gender. Also, among the Iranian ethnicities, Kurd had the lowest chance while Gilak and Azari had the highest chance of developing PCAD as compared to the Fars ethnicity. Investigation of the behavioral and psychological dimensions indicated that stress was significantly higher among those without coronary artery involvement as compared to those with this involvement. The decision tree model could predict that among Gilakis, Fasting blood sugar (FBS) above 126 and in Lurs opium as well as diastolic blood pressure above 85, and in Kurds male gender would considerably increase the odds of developing CAD. Conclusion: The model obtained from the decision tree indicated that although variables of age, gender, cigarette, and opium are among the main risk factors for involvement of coronary arteries among young adult patients, in different ethnicities, the risk level of each of these risk factors in incidence of PCAD is different. This means among Kurds, age, among Gilakis diabetes, and among Lurs opium are more important.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-49.pdfethnic differencespremature coronary artery diseasedecision treemulticentercase-control study |
| spellingShingle | Seyed Ali Moezi Bady Fatemeh Salmani Ehsan Zarepur Toba Kazemi Neda Partovi Nazanin Hanafi Bojd Saeede Khosravi Bizhaem Alireza Khosravi Farsani Noushin Mohammadifard Fereidoon Nouhi Hassan Alikhasi Masoumeh Sadeghi Hamidreza Roohafza Razieh Hassannejad Katayoun Rabiei Nahid Salehi Kamal Solati Masoud Lotfizadeh Samad Ghaffari Elmira Javanmardi Arsalan Salari Mostafa Dehghani Mostafa Cheraghi Habib Haybar Reza Madadi Nahid Azdaki Nizal Sarrafzadegan Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) Journal of Cardiovascular and Thoracic Research ethnic differences premature coronary artery disease decision tree multicenter case-control study |
| title | Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) |
| title_full | Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) |
| title_fullStr | Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) |
| title_full_unstemmed | Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) |
| title_short | Investigating ethnic differences in risk factors and severity of developing premature coronary artery disease: Predicting the effect of risk factors through decision tree analysis in a multicenter case-control study; Results from Iran Premature Coronary Artery Disease (IPAD study) |
| title_sort | investigating ethnic differences in risk factors and severity of developing premature coronary artery disease predicting the effect of risk factors through decision tree analysis in a multicenter case control study results from iran premature coronary artery disease ipad study |
| topic | ethnic differences premature coronary artery disease decision tree multicenter case-control study |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-17-49.pdf |
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