Nephrotic-range proteinuria in a 53-year-old female with thin basement membrane nephropathy: A case report with literature review
Thin basement membrane nephropathy is traditionally characterized by persistent microscopic hematuria and minimal proteinuria, and has long been considered a benign condition. However, emerging evidence challenges this view, as thin basement membrane nephropathy can occasionally present with nephrot...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-08-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251365367 |
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| Summary: | Thin basement membrane nephropathy is traditionally characterized by persistent microscopic hematuria and minimal proteinuria, and has long been considered a benign condition. However, emerging evidence challenges this view, as thin basement membrane nephropathy can occasionally present with nephrotic-range proteinuria. We report a case of a 53-year-old female with isolated nephrotic-range proteinuria, ultimately diagnosed with thin basement membrane nephropathy based on electron microscopy findings. Her proteinuria improved significantly over a 10-month period with angiotensin-converting enzyme inhibitor therapy, lisinopril 40 mg once daily. This case adds to the growing recognition that thin basement membrane nephropathy may not always follow a benign course and highlights the importance of careful evaluation and management when clinical features fall outside the expected pattern. A comprehensive literature review is also provided, summarizing similar presentations and management strategies. |
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| ISSN: | 2050-313X |