Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review
Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and imm...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/9170480 |
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| author | Patrycja Kurowska Alix Barbe Marta Różycka Justyna Chmielińska Joelle Dupont Agnieszka Rak |
| author_facet | Patrycja Kurowska Alix Barbe Marta Różycka Justyna Chmielińska Joelle Dupont Agnieszka Rak |
| author_sort | Patrycja Kurowska |
| collection | DOAJ |
| description | Apelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue. Thus, apelin is synthesized locally in the hypothalamus, pituitary, ovaries, and testis of many species and has autocrine and/or paracrine effects. Most research indicates that apelin has an inhibitory effect on gonadotropin secretion and participates in the direct regulation of steroidogenesis, cell proliferation, and apoptosis in gonads. The article summarizes also results of a series of recent studies on the effect of apelin on reproduction pathology, like polycystic ovarian syndrome, endometriosis, and ovarian cancer. Many of these pathologies are still in critical need of therapeutic intervention, and recent studies have found that apelin can be targets in reproductive pathological states. |
| format | Article |
| id | doaj-art-0cdb1b1d05a8495493852bd59d26af29 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-0cdb1b1d05a8495493852bd59d26af292025-02-03T01:10:03ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/91704809170480Apelin in Reproductive Physiology and Pathology of Different Species: A Critical ReviewPatrycja Kurowska0Alix Barbe1Marta Różycka2Justyna Chmielińska3Joelle Dupont4Agnieszka Rak5Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, PolandINRA, Unité Physiologie de la Reproduction et des Comportements, 37-380 Nouzilly, FranceDepartment of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, PolandDepartment of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, PolandINRA, Unité Physiologie de la Reproduction et des Comportements, 37-380 Nouzilly, FranceDepartment of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, PolandApelin has been isolated from the bovine stomach extracts as an endogenous ligand of the previously orphan receptor APJ. Expression of the apelinergic system (apelin and APJ) was described in many organs where pleiotropic effects like regulation of food intake, body weight, or cardiovascular and immune function were described. Recent studies have shown that apelin also plays an important role in the regulation of female and male reproduction. Some data showed that the gene and protein of apelin/APJ are expressed in the hypothalamic-pituitary-gonad (HPG) axis tissue. Thus, apelin is synthesized locally in the hypothalamus, pituitary, ovaries, and testis of many species and has autocrine and/or paracrine effects. Most research indicates that apelin has an inhibitory effect on gonadotropin secretion and participates in the direct regulation of steroidogenesis, cell proliferation, and apoptosis in gonads. The article summarizes also results of a series of recent studies on the effect of apelin on reproduction pathology, like polycystic ovarian syndrome, endometriosis, and ovarian cancer. Many of these pathologies are still in critical need of therapeutic intervention, and recent studies have found that apelin can be targets in reproductive pathological states.http://dx.doi.org/10.1155/2018/9170480 |
| spellingShingle | Patrycja Kurowska Alix Barbe Marta Różycka Justyna Chmielińska Joelle Dupont Agnieszka Rak Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review International Journal of Endocrinology |
| title | Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review |
| title_full | Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review |
| title_fullStr | Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review |
| title_full_unstemmed | Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review |
| title_short | Apelin in Reproductive Physiology and Pathology of Different Species: A Critical Review |
| title_sort | apelin in reproductive physiology and pathology of different species a critical review |
| url | http://dx.doi.org/10.1155/2018/9170480 |
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