Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen
Introduction. Granulocyte colony-stimulating factor (G-CSF) is commonly used for prevention and treatment of febrile neutropenia among solid tumor patients. It is considered an effective and relatively safe supportive care medication; however, it can cause rare and serious side effects such as splee...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/8174986 |
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| author | Majed A. Alshamrani Meteb Al-Foheidi Ahmed H. Abdulrahim |
| author_facet | Majed A. Alshamrani Meteb Al-Foheidi Ahmed H. Abdulrahim |
| author_sort | Majed A. Alshamrani |
| collection | DOAJ |
| description | Introduction. Granulocyte colony-stimulating factor (G-CSF) is commonly used for prevention and treatment of febrile neutropenia among solid tumor patients. It is considered an effective and relatively safe supportive care medication; however, it can cause rare and serious side effects such as spleen rupture or infarction. Case Presentation. We are reporting a case of a 27-year-old female with breast cancer who has been treated with dose-dense chemotherapy and received colony-stimulating factor as primary prevention of febrile neutropenia that was complicated halfway through with splenic infarction. This finding was confirmed by computed tomography (CT) scan and splenic biopsy. Management was conservative without the need of surgical intervention. Conclusion. Although splenic infarction is an extremely rare side effect of G-CSF, it can be a serious complication that should be recognized, monitored, and managed carefully. |
| format | Article |
| id | doaj-art-0cd5bbd059384caf85e1d27c6c11687a |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-0cd5bbd059384caf85e1d27c6c11687a2025-02-03T05:49:57ZengWileyCase Reports in Oncological Medicine2090-67062090-67142019-01-01201910.1155/2019/81749868174986Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy RegimenMajed A. Alshamrani0Meteb Al-Foheidi1Ahmed H. Abdulrahim2Department of Pharmaceutical Care Services, Ministry of National Guard-Health Affairs, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Saudi ArabiaKing Abdullah International Medical Research Center, Saudi ArabiaIntroduction. Granulocyte colony-stimulating factor (G-CSF) is commonly used for prevention and treatment of febrile neutropenia among solid tumor patients. It is considered an effective and relatively safe supportive care medication; however, it can cause rare and serious side effects such as spleen rupture or infarction. Case Presentation. We are reporting a case of a 27-year-old female with breast cancer who has been treated with dose-dense chemotherapy and received colony-stimulating factor as primary prevention of febrile neutropenia that was complicated halfway through with splenic infarction. This finding was confirmed by computed tomography (CT) scan and splenic biopsy. Management was conservative without the need of surgical intervention. Conclusion. Although splenic infarction is an extremely rare side effect of G-CSF, it can be a serious complication that should be recognized, monitored, and managed carefully.http://dx.doi.org/10.1155/2019/8174986 |
| spellingShingle | Majed A. Alshamrani Meteb Al-Foheidi Ahmed H. Abdulrahim Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen Case Reports in Oncological Medicine |
| title | Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen |
| title_full | Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen |
| title_fullStr | Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen |
| title_full_unstemmed | Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen |
| title_short | Granulocyte Colony Stimulating Factor (G-CSF) Induced Splenic Infarction in Breast Cancer Patient Treated with Dose-Dense Chemotherapy Regimen |
| title_sort | granulocyte colony stimulating factor g csf induced splenic infarction in breast cancer patient treated with dose dense chemotherapy regimen |
| url | http://dx.doi.org/10.1155/2019/8174986 |
| work_keys_str_mv | AT majedaalshamrani granulocytecolonystimulatingfactorgcsfinducedsplenicinfarctioninbreastcancerpatienttreatedwithdosedensechemotherapyregimen AT metebalfoheidi granulocytecolonystimulatingfactorgcsfinducedsplenicinfarctioninbreastcancerpatienttreatedwithdosedensechemotherapyregimen AT ahmedhabdulrahim granulocytecolonystimulatingfactorgcsfinducedsplenicinfarctioninbreastcancerpatienttreatedwithdosedensechemotherapyregimen |