Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins
Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to ca...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/676731 |
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| _version_ | 1832558774373580800 |
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| author | Gerd Bendas Lubor Borsig |
| author_facet | Gerd Bendas Lubor Borsig |
| author_sort | Gerd Bendas |
| collection | DOAJ |
| description | Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression. This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and antimetastatic activities of heparin. |
| format | Article |
| id | doaj-art-0cc0704b1fdb4a8aa5fd383903acf759 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-0cc0704b1fdb4a8aa5fd383903acf7592025-02-03T01:31:34ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/676731676731Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of HeparinsGerd Bendas0Lubor Borsig1Department of Pharmaceutical Chemistry, University of Bonn, 53121 Bonn, GermanyInstitute of Physiology, University of Zürich and Zürich Center for Integrative Human Physiology, 8057 Zürich, SwitzerlandCell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Clinical evidence indicates that heparin, commonly used for treatment of thromboembolic events in cancer patients, is beneficial for their survival. Preclinical studies confirm that heparin possesses antimetastatic activities that lead to attenuation of metastasis in various animal models. Heparin contains several biological activities that may affect several steps in metastatic cascade. Here we focus on the role of cellular adhesion receptors in the metastatic cascade and discuss evidence for heparin as an inhibitor of cell adhesion. While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression. This review summarizes recent findings about potential mechanisms of tumor cell interactions in the vasculature and antimetastatic activities of heparin.http://dx.doi.org/10.1155/2012/676731 |
| spellingShingle | Gerd Bendas Lubor Borsig Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins International Journal of Cell Biology |
| title | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins |
| title_full | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins |
| title_fullStr | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins |
| title_full_unstemmed | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins |
| title_short | Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins |
| title_sort | cancer cell adhesion and metastasis selectins integrins and the inhibitory potential of heparins |
| url | http://dx.doi.org/10.1155/2012/676731 |
| work_keys_str_mv | AT gerdbendas cancercelladhesionandmetastasisselectinsintegrinsandtheinhibitorypotentialofheparins AT luborborsig cancercelladhesionandmetastasisselectinsintegrinsandtheinhibitorypotentialofheparins |