Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats
Red honeybush tea (RHT) is a tea product developed from Cyclopia spp. which is endemic to South Africa. Aside refreshment, RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes. This study investigated the in vivo antioxidant and anti-diabetic...
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000708 |
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| author | Xin Xiao Ochuko L. Erukainure Md. Shahidul Islam |
| author_facet | Xin Xiao Ochuko L. Erukainure Md. Shahidul Islam |
| author_sort | Xin Xiao |
| collection | DOAJ |
| description | Red honeybush tea (RHT) is a tea product developed from Cyclopia spp. which is endemic to South Africa. Aside refreshment, RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes. This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes (T2D) model of rats. T2D was induced starting with feeding 10 % fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight (BW)). Five weeks of treatment of RHT led to significant (P < 0.05) elevation in serum insulin, pancreatic β-cell function, HDL-c levels with concomitant decrease in AST, ALT, ALP, urea, CK-MB, fructosamine, total cholesterol, triglycerides, LDL-c, and insulin resistance in diabetic rats. RHT also significantly (P < 0.05) decreased MDA levels and enhanced level of GSH, activity of SOD, catalase, GR in most of organs (pancreas, liver, kidneys, and heart). Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats. |
| format | Article |
| id | doaj-art-0cbae7d03eed440498bd15a6e0fc8376 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-0cbae7d03eed440498bd15a6e0fc83762025-02-03T05:55:57ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112620292039Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic ratsXin Xiao0Ochuko L. Erukainure1Md. Shahidul Islam2Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South AfricaDepartment of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa; Department of Pharmacology, University of the Free State, Bloemfontein 9300, South AfricaDepartment of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa; Corresponding author at: Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.Red honeybush tea (RHT) is a tea product developed from Cyclopia spp. which is endemic to South Africa. Aside refreshment, RHT has over the years been used traditionally in the treatment of various diseases including type 2 diabetes. This study investigated the in vivo antioxidant and anti-diabetic activity of RHT concentrated hot water extract in type 2 diabetes (T2D) model of rats. T2D was induced starting with feeding 10 % fructose solution ad libitum for 2 weeks followed by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight (BW)). Five weeks of treatment of RHT led to significant (P < 0.05) elevation in serum insulin, pancreatic β-cell function, HDL-c levels with concomitant decrease in AST, ALT, ALP, urea, CK-MB, fructosamine, total cholesterol, triglycerides, LDL-c, and insulin resistance in diabetic rats. RHT also significantly (P < 0.05) decreased MDA levels and enhanced level of GSH, activity of SOD, catalase, GR in most of organs (pancreas, liver, kidneys, and heart). Significantly (P < 0.05) improved morphological changes in the islets and β-cells were observed in rats treated with RHT. The data of this study suggest that RHT demonstrates an outstanding antioxidant and anti-diabetic effects in STZ-induced T2D model of rats.http://www.sciencedirect.com/science/article/pii/S2213453023000708Red honeybush tea (Cyclopia genistoides)AntioxidantsAnti-diabetesand Type 2 diabetes |
| spellingShingle | Xin Xiao Ochuko L. Erukainure Md. Shahidul Islam Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats Food Science and Human Wellness Red honeybush tea (Cyclopia genistoides) Antioxidants Anti-diabetes and Type 2 diabetes |
| title | Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats |
| title_full | Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats |
| title_fullStr | Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats |
| title_full_unstemmed | Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats |
| title_short | Red honeybush (Cyclopia genistoides) tea mitigates oxidative imbalance and hyperlipidemia, while improving glucose homeostasis in type 2 diabetic rats |
| title_sort | red honeybush cyclopia genistoides tea mitigates oxidative imbalance and hyperlipidemia while improving glucose homeostasis in type 2 diabetic rats |
| topic | Red honeybush tea (Cyclopia genistoides) Antioxidants Anti-diabetes and Type 2 diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000708 |
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