A Role for Folate in Microbiome-Linked Control of Autoimmunity
The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis. In part, this is due to direct effect...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9998200 |
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| author | Christine Mölzer Heather M. Wilson Lucia Kuffova John V. Forrester |
| author_facet | Christine Mölzer Heather M. Wilson Lucia Kuffova John V. Forrester |
| author_sort | Christine Mölzer |
| collection | DOAJ |
| description | The microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis. In part, this is due to direct effects of the microbiome on gastrointestinal (GI) physiology and nutrient transport, but also to indirect effects on immunoregulatory controls, including induction and stabilization of T regulatory cells (Treg). Secreted bacterial metabolites such as short-chain fatty acids (SCFA) are under intense investigation as mediators of these effects. In contrast, folate (vitamin B9), an essential micronutrient, has attracted less attention, possibly because it exerts global physiological effects which are difficult to differentiate from specific effects on the immune system. Here, we review the role of folate in AD/AID with some emphasis on sight-threatening autoimmune uveitis. Since folate is required for the generation and maintenance of Treg, we propose that one mechanism for microbiome-based control of AD/AID is via folate-dependent induction of GI tract Treg, particularly colonic Treg, via anergic T cells (Tan). Hence, folate supplementation has potential prophylactic and/or therapeutic benefit in AID/AD. |
| format | Article |
| id | doaj-art-0cb8a28ec3084732ac2060b4f1f52504 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0cb8a28ec3084732ac2060b4f1f525042025-02-03T06:46:14ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/99982009998200A Role for Folate in Microbiome-Linked Control of AutoimmunityChristine Mölzer0Heather M. Wilson1Lucia Kuffova2John V. Forrester3University of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UKUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UKUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UKUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UKThe microbiome exerts considerable control over immune homeostasis and influences susceptibility to autoimmune and autoinflammatory disease (AD/AID) such as inflammatory bowel disease (IBD), multiple sclerosis (MS), type 1 diabetes (T1D), psoriasis, and uveitis. In part, this is due to direct effects of the microbiome on gastrointestinal (GI) physiology and nutrient transport, but also to indirect effects on immunoregulatory controls, including induction and stabilization of T regulatory cells (Treg). Secreted bacterial metabolites such as short-chain fatty acids (SCFA) are under intense investigation as mediators of these effects. In contrast, folate (vitamin B9), an essential micronutrient, has attracted less attention, possibly because it exerts global physiological effects which are difficult to differentiate from specific effects on the immune system. Here, we review the role of folate in AD/AID with some emphasis on sight-threatening autoimmune uveitis. Since folate is required for the generation and maintenance of Treg, we propose that one mechanism for microbiome-based control of AD/AID is via folate-dependent induction of GI tract Treg, particularly colonic Treg, via anergic T cells (Tan). Hence, folate supplementation has potential prophylactic and/or therapeutic benefit in AID/AD.http://dx.doi.org/10.1155/2021/9998200 |
| spellingShingle | Christine Mölzer Heather M. Wilson Lucia Kuffova John V. Forrester A Role for Folate in Microbiome-Linked Control of Autoimmunity Journal of Immunology Research |
| title | A Role for Folate in Microbiome-Linked Control of Autoimmunity |
| title_full | A Role for Folate in Microbiome-Linked Control of Autoimmunity |
| title_fullStr | A Role for Folate in Microbiome-Linked Control of Autoimmunity |
| title_full_unstemmed | A Role for Folate in Microbiome-Linked Control of Autoimmunity |
| title_short | A Role for Folate in Microbiome-Linked Control of Autoimmunity |
| title_sort | role for folate in microbiome linked control of autoimmunity |
| url | http://dx.doi.org/10.1155/2021/9998200 |
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