T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer
The competent immune system controls disease effectively due to induction, function, and regulation of effector lymphocytes. Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression. In squamous cell...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2010/236378 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551231592071168 |
|---|---|
| author | A. E. Albers L. Strauss T. Liao T. K. Hoffmann A. M. Kaufmann |
| author_facet | A. E. Albers L. Strauss T. Liao T. K. Hoffmann A. M. Kaufmann |
| author_sort | A. E. Albers |
| collection | DOAJ |
| description | The competent immune system controls disease effectively due to induction, function, and regulation of effector lymphocytes. Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression. In squamous cell carcinoma of the head and neck, the presence, activity, but also suppression of tumor-specific CTL have been demonstrated. Functional CTL may exert a selection pressure on the tumor cells that consecutively escape by a combination of molecular and cellular evasion mechanisms. Certain of these mechanisms target antitumor effector cells directly or indirectly by affecting cells that regulate CTL function. This results in the dysfunction or apoptosis of lymphocytes and dysregulated lymphocyte homeostasis. Another important tumor-escape mechanism is to avoid recognition by dysregulation of antigen processing and presentation. Thus, both induction of functional CTL and susceptibility of the tumor and its microenvironment to become T cell targets should be considered in CTL-based immunotherapy. |
| format | Article |
| id | doaj-art-0cb495073b19409588d0bd40eaf15308 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0cb495073b19409588d0bd40eaf153082025-02-03T06:01:54ZengWileyClinical and Developmental Immunology1740-25221740-25302010-01-01201010.1155/2010/236378236378T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck CancerA. E. Albers0L. Strauss1T. Liao2T. K. Hoffmann3A. M. Kaufmann4Department of Otolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200 Berlin, GermanyFondazione Humanitas per la Ricerca, 20089 Rozzano, ItalyDepartment of Otolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200 Berlin, GermanyDepartment of Otolaryngology, Head and Neck Surgery, Universität Essen, 45147 Essen, GermanyDepartment of Gynecology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin and Campus Mitte, 12200 Berlin, GermanyThe competent immune system controls disease effectively due to induction, function, and regulation of effector lymphocytes. Immunosurveillance is exerted mostly by cytotoxic T-lymphocytes (CTLs) while specific immune suppression is associated with tumor malignancy and progression. In squamous cell carcinoma of the head and neck, the presence, activity, but also suppression of tumor-specific CTL have been demonstrated. Functional CTL may exert a selection pressure on the tumor cells that consecutively escape by a combination of molecular and cellular evasion mechanisms. Certain of these mechanisms target antitumor effector cells directly or indirectly by affecting cells that regulate CTL function. This results in the dysfunction or apoptosis of lymphocytes and dysregulated lymphocyte homeostasis. Another important tumor-escape mechanism is to avoid recognition by dysregulation of antigen processing and presentation. Thus, both induction of functional CTL and susceptibility of the tumor and its microenvironment to become T cell targets should be considered in CTL-based immunotherapy.http://dx.doi.org/10.1155/2010/236378 |
| spellingShingle | A. E. Albers L. Strauss T. Liao T. K. Hoffmann A. M. Kaufmann T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer Clinical and Developmental Immunology |
| title | T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer |
| title_full | T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer |
| title_fullStr | T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer |
| title_full_unstemmed | T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer |
| title_short | T Cell-Tumor Interaction Directs the Development of Immunotherapies in Head and Neck Cancer |
| title_sort | t cell tumor interaction directs the development of immunotherapies in head and neck cancer |
| url | http://dx.doi.org/10.1155/2010/236378 |
| work_keys_str_mv | AT aealbers tcelltumorinteractiondirectsthedevelopmentofimmunotherapiesinheadandneckcancer AT lstrauss tcelltumorinteractiondirectsthedevelopmentofimmunotherapiesinheadandneckcancer AT tliao tcelltumorinteractiondirectsthedevelopmentofimmunotherapiesinheadandneckcancer AT tkhoffmann tcelltumorinteractiondirectsthedevelopmentofimmunotherapiesinheadandneckcancer AT amkaufmann tcelltumorinteractiondirectsthedevelopmentofimmunotherapiesinheadandneckcancer |