Statins as Modulators of Regulatory T-Cell Biology
Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseas...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/167086 |
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| _version_ | 1832564310790897664 |
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| author | David A. Forero-Peña Fredy R. S. Gutierrez |
| author_facet | David A. Forero-Peña Fredy R. S. Gutierrez |
| author_sort | David A. Forero-Peña |
| collection | DOAJ |
| description | Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms. On the other hand, the induction and activity of regulatory T cells (Treg) are key processes in the prevention of pathology during chronic inflammatory and autoimmune diseases. Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers. The potential effects of statins on the biology of Treg are of particular importance because of their eventual application as in vivo inducers of Treg in the treatment of multiple conditions. In this paper we review the experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions and discuss its potential clinical significance. |
| format | Article |
| id | doaj-art-0ca87f183ccb4bc7b8ac9b70f5224daa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0ca87f183ccb4bc7b8ac9b70f5224daa2025-02-03T01:11:16ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/167086167086Statins as Modulators of Regulatory T-Cell BiologyDavid A. Forero-Peña0Fredy R. S. Gutierrez1Grupo de Investigación en Ciencias Biomédicas, Facultad de Medicina, Universidad Antonio Nariño, Bogotá, ColombiaGrupo de Investigación en Ciencias Biomédicas, Facultad de Medicina, Universidad Antonio Nariño, Bogotá, ColombiaStatins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol. Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms. On the other hand, the induction and activity of regulatory T cells (Treg) are key processes in the prevention of pathology during chronic inflammatory and autoimmune diseases. Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers. The potential effects of statins on the biology of Treg are of particular importance because of their eventual application as in vivo inducers of Treg in the treatment of multiple conditions. In this paper we review the experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions and discuss its potential clinical significance.http://dx.doi.org/10.1155/2013/167086 |
| spellingShingle | David A. Forero-Peña Fredy R. S. Gutierrez Statins as Modulators of Regulatory T-Cell Biology Mediators of Inflammation |
| title | Statins as Modulators of Regulatory T-Cell Biology |
| title_full | Statins as Modulators of Regulatory T-Cell Biology |
| title_fullStr | Statins as Modulators of Regulatory T-Cell Biology |
| title_full_unstemmed | Statins as Modulators of Regulatory T-Cell Biology |
| title_short | Statins as Modulators of Regulatory T-Cell Biology |
| title_sort | statins as modulators of regulatory t cell biology |
| url | http://dx.doi.org/10.1155/2013/167086 |
| work_keys_str_mv | AT davidaforeropena statinsasmodulatorsofregulatorytcellbiology AT fredyrsgutierrez statinsasmodulatorsofregulatorytcellbiology |