Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus
Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flaviv...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6106582 |
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| author | Hong-Yan Guo Xing-Cui Zhang Ren-Yong Jia |
| author_facet | Hong-Yan Guo Xing-Cui Zhang Ren-Yong Jia |
| author_sort | Hong-Yan Guo |
| collection | DOAJ |
| description | Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flavivirus infections yet. Innate immunity is the first line of defense in resisting pathogen invasion, serving an important role in a resisting virus. Toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) are crucial pattern recognition receptors (PRRs) that play essential roles in recognizing and clearing pathogens, including resisting flavivirus. In the present review, we provide a significant reference for further research on the function of innate immunity in resisting flavivirus. |
| format | Article |
| id | doaj-art-0c968070d59d49948c0cebbbd6226db6 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0c968070d59d49948c0cebbbd6226db62025-02-03T01:11:09ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/61065826106582Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting FlavivirusHong-Yan Guo0Xing-Cui Zhang1Ren-Yong Jia2Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130 Sichuan Province, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130 Sichuan Province, ChinaResearch Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130 Sichuan Province, ChinaFlaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries. Even though people and animals are barraged with flavivirus infection every year, we have not invented either vaccines or antiviral for most flavivirus infections yet. Innate immunity is the first line of defense in resisting pathogen invasion, serving an important role in a resisting virus. Toll-like receptors (TLRs) and retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) are crucial pattern recognition receptors (PRRs) that play essential roles in recognizing and clearing pathogens, including resisting flavivirus. In the present review, we provide a significant reference for further research on the function of innate immunity in resisting flavivirus.http://dx.doi.org/10.1155/2018/6106582 |
| spellingShingle | Hong-Yan Guo Xing-Cui Zhang Ren-Yong Jia Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus Journal of Immunology Research |
| title | Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus |
| title_full | Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus |
| title_fullStr | Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus |
| title_full_unstemmed | Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus |
| title_short | Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus |
| title_sort | toll like receptors and rig i like receptors play important roles in resisting flavivirus |
| url | http://dx.doi.org/10.1155/2018/6106582 |
| work_keys_str_mv | AT hongyanguo tolllikereceptorsandrigilikereceptorsplayimportantrolesinresistingflavivirus AT xingcuizhang tolllikereceptorsandrigilikereceptorsplayimportantrolesinresistingflavivirus AT renyongjia tolllikereceptorsandrigilikereceptorsplayimportantrolesinresistingflavivirus |