Targeting Herpetic Keratitis by Gene Therapy
Ocular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness. Re...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/594869 |
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| _version_ | 1832565420577521664 |
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| author | Hossein Mostafa Elbadawy Marine Gailledrat Carole Desseaux Diego Ponzin Stefano Ferrari |
| author_facet | Hossein Mostafa Elbadawy Marine Gailledrat Carole Desseaux Diego Ponzin Stefano Ferrari |
| author_sort | Hossein Mostafa Elbadawy |
| collection | DOAJ |
| description | Ocular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness. Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution. This paper will focus on the current situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies. Whereas the correction of inherited diseases was the initial goal of the field of gene therapy, here we discuss transgene expression, gene replacement, silencing, or clipping. Gene therapy of herpetic keratitis previously reported in the literature is screened emphasizing candidate gene therapy targets. Commonly adopted strategies are discussed to assess the relative advantages of the protective therapy using antiviral drugs and the common gene therapy against long-term HSV-1 ocular infections signs, inflammation and neovascularization. Successful gene therapy can provide innovative physiological and pharmaceutical solutions against herpetic keratitis. |
| format | Article |
| id | doaj-art-0c81389f81d64dd1b23093473a51c1fb |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-0c81389f81d64dd1b23093473a51c1fb2025-02-03T01:07:44ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/594869594869Targeting Herpetic Keratitis by Gene TherapyHossein Mostafa Elbadawy0Marine Gailledrat1Carole Desseaux2Diego Ponzin3Stefano Ferrari4The Veneto Eye Bank Foundation, Via Paccagnella 11, Padiglione Giovanni Rama, Zelarino, 30174 Venice, ItalyCellectis Therapeutics SAS, 8 rue de la Croix Jarry, 75013 Paris, FranceCellectis Therapeutics SAS, 8 rue de la Croix Jarry, 75013 Paris, FranceThe Veneto Eye Bank Foundation, Via Paccagnella 11, Padiglione Giovanni Rama, Zelarino, 30174 Venice, ItalyThe Veneto Eye Bank Foundation, Via Paccagnella 11, Padiglione Giovanni Rama, Zelarino, 30174 Venice, ItalyOcular gene therapy is rapidly becoming a reality. By November 2012, approximately 28 clinical trials were approved to assess novel gene therapy agents. Viral infections such as herpetic keratitis caused by herpes simplex virus 1 (HSV-1) can cause serious complications that may lead to blindness. Recurrence of the disease is likely and cornea transplantation, therefore, might not be the ideal therapeutic solution. This paper will focus on the current situation of ocular gene therapy research against herpetic keratitis, including the use of viral and nonviral vectors, routes of delivery of therapeutic genes, new techniques, and key research strategies. Whereas the correction of inherited diseases was the initial goal of the field of gene therapy, here we discuss transgene expression, gene replacement, silencing, or clipping. Gene therapy of herpetic keratitis previously reported in the literature is screened emphasizing candidate gene therapy targets. Commonly adopted strategies are discussed to assess the relative advantages of the protective therapy using antiviral drugs and the common gene therapy against long-term HSV-1 ocular infections signs, inflammation and neovascularization. Successful gene therapy can provide innovative physiological and pharmaceutical solutions against herpetic keratitis.http://dx.doi.org/10.1155/2012/594869 |
| spellingShingle | Hossein Mostafa Elbadawy Marine Gailledrat Carole Desseaux Diego Ponzin Stefano Ferrari Targeting Herpetic Keratitis by Gene Therapy Journal of Ophthalmology |
| title | Targeting Herpetic Keratitis by Gene Therapy |
| title_full | Targeting Herpetic Keratitis by Gene Therapy |
| title_fullStr | Targeting Herpetic Keratitis by Gene Therapy |
| title_full_unstemmed | Targeting Herpetic Keratitis by Gene Therapy |
| title_short | Targeting Herpetic Keratitis by Gene Therapy |
| title_sort | targeting herpetic keratitis by gene therapy |
| url | http://dx.doi.org/10.1155/2012/594869 |
| work_keys_str_mv | AT hosseinmostafaelbadawy targetingherpetickeratitisbygenetherapy AT marinegailledrat targetingherpetickeratitisbygenetherapy AT caroledesseaux targetingherpetickeratitisbygenetherapy AT diegoponzin targetingherpetickeratitisbygenetherapy AT stefanoferrari targetingherpetickeratitisbygenetherapy |