Prostaglandin Receptor Signaling in Disease
Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.182 |
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| _version_ | 1832558773893332992 |
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| author | Toshiyuki Matsuoka Shuh Narumiya |
| author_facet | Toshiyuki Matsuoka Shuh Narumiya |
| author_sort | Toshiyuki Matsuoka |
| collection | DOAJ |
| description | Prostanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding to a G-protein coupled rhodopsin-type receptor on the surface of target cells. There are eight types of the prostanoid receptors conserved in mammals from mouse to human. They are the PGD receptor (DP), four subtypes of the PGE receptor (EP1, EP2, EP3, and EP4), the PGF receptor (FP), PGI receptor (IP), and TXA receptor (TP). Recently, mice deficient in each of these prostanoid receptors were generated and subjected to various experimental models of disease. These studies have revealed the roles of PG receptor signaling in various pathological conditions, and suggest that selective manipulation of the prostanoid receptors may be beneficial in treatment of the pathological conditions. Here we review these recent findings of roles of prostanoid receptor signaling and their therapeutic implications. |
| format | Article |
| id | doaj-art-0c762caf5a074c00a43d55bbf04c6fa9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0c762caf5a074c00a43d55bbf04c6fa92025-02-03T01:31:29ZengWileyThe Scientific World Journal1537-744X2007-01-0171329134710.1100/tsw.2007.182Prostaglandin Receptor Signaling in DiseaseToshiyuki Matsuoka0Shuh Narumiya1Department of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606-8501, JapanDepartment of Pharmacology, Faculty of Medicine, Kyoto University, Kyoto 606-8501, JapanProstanoids, consisting of the prostaglandins (PGs) and the thromboxanes (TXs), are a group of lipid mediators formed in response to various stimuli. They include PGD2, PGE2, PGF2α, PGI2, and TXA2. They are released outside of the cells immediately after synthesis, and exert their actions by binding to a G-protein coupled rhodopsin-type receptor on the surface of target cells. There are eight types of the prostanoid receptors conserved in mammals from mouse to human. They are the PGD receptor (DP), four subtypes of the PGE receptor (EP1, EP2, EP3, and EP4), the PGF receptor (FP), PGI receptor (IP), and TXA receptor (TP). Recently, mice deficient in each of these prostanoid receptors were generated and subjected to various experimental models of disease. These studies have revealed the roles of PG receptor signaling in various pathological conditions, and suggest that selective manipulation of the prostanoid receptors may be beneficial in treatment of the pathological conditions. Here we review these recent findings of roles of prostanoid receptor signaling and their therapeutic implications.http://dx.doi.org/10.1100/tsw.2007.182 |
| spellingShingle | Toshiyuki Matsuoka Shuh Narumiya Prostaglandin Receptor Signaling in Disease The Scientific World Journal |
| title | Prostaglandin Receptor Signaling in Disease |
| title_full | Prostaglandin Receptor Signaling in Disease |
| title_fullStr | Prostaglandin Receptor Signaling in Disease |
| title_full_unstemmed | Prostaglandin Receptor Signaling in Disease |
| title_short | Prostaglandin Receptor Signaling in Disease |
| title_sort | prostaglandin receptor signaling in disease |
| url | http://dx.doi.org/10.1100/tsw.2007.182 |
| work_keys_str_mv | AT toshiyukimatsuoka prostaglandinreceptorsignalingindisease AT shuhnarumiya prostaglandinreceptorsignalingindisease |