Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography
The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolut...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/129760 |
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| author | Shreyasee Amin Sundeep Khosla |
| author_facet | Shreyasee Amin Sundeep Khosla |
| author_sort | Shreyasee Amin |
| collection | DOAJ |
| description | The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women. |
| format | Article |
| id | doaj-art-0c719891b213456d8f2cd0daa81e24dc |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-0c719891b213456d8f2cd0daa81e24dc2025-02-03T06:06:10ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/129760129760Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed TomographyShreyasee Amin0Sundeep Khosla1Division of Rheumatology, Department of Internal Medicine, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USADivision of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USAThe trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women.http://dx.doi.org/10.1155/2012/129760 |
| spellingShingle | Shreyasee Amin Sundeep Khosla Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography Journal of Osteoporosis |
| title | Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women
Assessed by High-Resolution Peripheral Quantitative Computed Tomography |
| title_full | Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women
Assessed by High-Resolution Peripheral Quantitative Computed Tomography |
| title_fullStr | Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women
Assessed by High-Resolution Peripheral Quantitative Computed Tomography |
| title_full_unstemmed | Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women
Assessed by High-Resolution Peripheral Quantitative Computed Tomography |
| title_short | Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women
Assessed by High-Resolution Peripheral Quantitative Computed Tomography |
| title_sort | sex and age related differences in bone microarchitecture in men relative to women assessed by high resolution peripheral quantitative computed tomography |
| url | http://dx.doi.org/10.1155/2012/129760 |
| work_keys_str_mv | AT shreyaseeamin sexandagerelateddifferencesinbonemicroarchitectureinmenrelativetowomenassessedbyhighresolutionperipheralquantitativecomputedtomography AT sundeepkhosla sexandagerelateddifferencesinbonemicroarchitectureinmenrelativetowomenassessedbyhighresolutionperipheralquantitativecomputedtomography |