Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case
Background. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2015/879538 |
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| author | Naushad A. B. Ahamed Khalid Sait Nisreen Anfnan Khader Farwan S. H. M. Nizamuddin Saleh S. Baeesa |
| author_facet | Naushad A. B. Ahamed Khalid Sait Nisreen Anfnan Khader Farwan S. H. M. Nizamuddin Saleh S. Baeesa |
| author_sort | Naushad A. B. Ahamed |
| collection | DOAJ |
| description | Background. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare occurrence. Case Presentation. A 21-year-old female presented with headache and left orbital swelling one year after resection of a complete hydatidiform mole followed by adjuvant methotrexate chemotherapy. A metastatic imaging screening revealed multiple metastases in the lungs, brain, and adrenal gland, in addition to the choroid and lacrimal gland. Based on her modified WHO risk factors scoring she was started on chemotherapy and whole brain radiotherapy, which resulted in a complete response. At two-year follow-up, serum b-HCG level was with normal limits; imaging surveillance was uneventful. Conclusion. We present the first case of lacrimal gland metastasis in a young girl from GC relapse. |
| format | Article |
| id | doaj-art-0c70b6a995a24ab793aa0ad156c94ca1 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0c70b6a995a24ab793aa0ad156c94ca12025-02-03T06:06:58ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922015-01-01201510.1155/2015/879538879538Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported CaseNaushad A. B. Ahamed0Khalid Sait1Nisreen Anfnan2Khader Farwan3S. H. M. Nizamuddin4Saleh S. Baeesa5Department of Radiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaGynecology Oncology Unit, Department of Obstetric and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaGynecology Oncology Unit, Department of Obstetric and Gynecology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Ophthalmology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDivision of Neurosurgery, Faculty of Medicine, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi ArabiaBackground. Gestational choriocarcinoma (GC) is a recognized clinicopathological subtype of gestational trophoblastic neoplasia that usually metastasizes hematogenously to highly vascular organs like the lung, liver, and brain. However, orbital metastasis to the choroid and lacrimal gland is a rare occurrence. Case Presentation. A 21-year-old female presented with headache and left orbital swelling one year after resection of a complete hydatidiform mole followed by adjuvant methotrexate chemotherapy. A metastatic imaging screening revealed multiple metastases in the lungs, brain, and adrenal gland, in addition to the choroid and lacrimal gland. Based on her modified WHO risk factors scoring she was started on chemotherapy and whole brain radiotherapy, which resulted in a complete response. At two-year follow-up, serum b-HCG level was with normal limits; imaging surveillance was uneventful. Conclusion. We present the first case of lacrimal gland metastasis in a young girl from GC relapse.http://dx.doi.org/10.1155/2015/879538 |
| spellingShingle | Naushad A. B. Ahamed Khalid Sait Nisreen Anfnan Khader Farwan S. H. M. Nizamuddin Saleh S. Baeesa Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case Case Reports in Obstetrics and Gynecology |
| title | Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case |
| title_full | Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case |
| title_fullStr | Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case |
| title_full_unstemmed | Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case |
| title_short | Gestational Choriocarcinoma Presenting with Lacrimal Gland Metastasis: A First Reported Case |
| title_sort | gestational choriocarcinoma presenting with lacrimal gland metastasis a first reported case |
| url | http://dx.doi.org/10.1155/2015/879538 |
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