The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability.

The antiangiogenic peptide VIAN-c4551 inhibits lung melanoma metastasis in mice by reducing pulmonary vascular permeability.

<h4>Introduction</h4>Cancer cells drive the increase in vascular permeability mediating tumor cell extravasation and metastatic seeding. VIAN-c4551, an antiangiogenic peptide analog of vasoinhibin, inhibits the growth and vascularization of melanoma tumors in mice. Because VIAN-c4551 is...

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Main Authors: Alma Lorena Perez, Magdalena Zamora, Manuel Bahena, Regina Aramburo-Williams, Elva Adan-Castro, Daniela Granados-Carrasco, Thomas Bertsch, Jakob Triebel, Gonzalo Martinez de la Escalera, Juan Pablo Robles, Carmen Clapp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0316983
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