Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period
Viral infections are one of the main causes of acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergence of A/H1N1pdm influenza virus in the 2009 pandemic changed the viral etiology of exacerbations that were reported before the pandemic. The aim of this study was to describe...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2015/560679 |
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| author | Ivan Sanz Sonia Tamames Silvia Rojo Mar Justel José Eugenio Lozano Carlos Disdier Tomás Vega Raúl Ortiz de Lejarazu |
| author_facet | Ivan Sanz Sonia Tamames Silvia Rojo Mar Justel José Eugenio Lozano Carlos Disdier Tomás Vega Raúl Ortiz de Lejarazu |
| author_sort | Ivan Sanz |
| collection | DOAJ |
| description | Viral infections are one of the main causes of acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergence of A/H1N1pdm influenza virus in the 2009 pandemic changed the viral etiology of exacerbations that were reported before the pandemic. The aim of this study was to describe the etiology of respiratory viruses in 195 Spanish patients affected by AE-COPD from the pandemic until the 2011-12 influenza epidemic. During the study period (2009–2012), respiratory viruses were identified in 48.7% of samples, and the proportion of viral detections in AE-COPD was higher in patients aged 30–64 years than ≥65 years. Influenza A viruses were the pathogens most often detected during the pandemic and the following two influenza epidemics in contradistinction to human rhino/enteroviruses that were the main viruses causing AE-COPD before the pandemic. The probability of influenza virus detection was 2.78-fold higher in patients who are 30–64 years old than those ≥65. Most respiratory samples were obtained during the pandemic, but the influenza detection rate was higher during the 2011-12 epidemic. There is a need for more accurate AE-COPD diagnosis, emphasizing the role of respiratory viruses. Furthermore, diagnosis requires increased attention to patient age and the characteristics of each influenza epidemic. |
| format | Article |
| id | doaj-art-0c5b4b203c43446bb51eeb54471d398e |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-0c5b4b203c43446bb51eeb54471d398e2025-02-03T05:45:31ZengWileyAdvances in Virology1687-86391687-86472015-01-01201510.1155/2015/560679560679Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic PeriodIvan Sanz0Sonia Tamames1Silvia Rojo2Mar Justel3José Eugenio Lozano4Carlos Disdier5Tomás Vega6Raúl Ortiz de Lejarazu7Valladolid National Influenza Centre, Avenida Ramón y Cajal No. 7, 47005 Valladolid, SpainConsejería de Sanidad, Junta de Castilla y León, Paseo de Zorrilla No. 1, 47007 Valladolid, SpainValladolid National Influenza Centre, Avenida Ramón y Cajal No. 7, 47005 Valladolid, SpainMicrobiology and Immunology Service, University Clinic Hospital of Valladolid, Avenida Ramón y Cajal s/n, 47005 Valladolid, SpainConsejería de Sanidad, Junta de Castilla y León, Paseo de Zorrilla No. 1, 47007 Valladolid, SpainPulmonology Service, University Clinic Hospital of Valladolid, Avenida Ramón y Cajal s/n, 47005 Valladolid, SpainConsejería de Sanidad, Junta de Castilla y León, Paseo de Zorrilla No. 1, 47007 Valladolid, SpainValladolid National Influenza Centre, Avenida Ramón y Cajal No. 7, 47005 Valladolid, SpainViral infections are one of the main causes of acute exacerbations of chronic obstructive pulmonary disease (AE-COPD). Emergence of A/H1N1pdm influenza virus in the 2009 pandemic changed the viral etiology of exacerbations that were reported before the pandemic. The aim of this study was to describe the etiology of respiratory viruses in 195 Spanish patients affected by AE-COPD from the pandemic until the 2011-12 influenza epidemic. During the study period (2009–2012), respiratory viruses were identified in 48.7% of samples, and the proportion of viral detections in AE-COPD was higher in patients aged 30–64 years than ≥65 years. Influenza A viruses were the pathogens most often detected during the pandemic and the following two influenza epidemics in contradistinction to human rhino/enteroviruses that were the main viruses causing AE-COPD before the pandemic. The probability of influenza virus detection was 2.78-fold higher in patients who are 30–64 years old than those ≥65. Most respiratory samples were obtained during the pandemic, but the influenza detection rate was higher during the 2011-12 epidemic. There is a need for more accurate AE-COPD diagnosis, emphasizing the role of respiratory viruses. Furthermore, diagnosis requires increased attention to patient age and the characteristics of each influenza epidemic.http://dx.doi.org/10.1155/2015/560679 |
| spellingShingle | Ivan Sanz Sonia Tamames Silvia Rojo Mar Justel José Eugenio Lozano Carlos Disdier Tomás Vega Raúl Ortiz de Lejarazu Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period Advances in Virology |
| title | Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period |
| title_full | Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period |
| title_fullStr | Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period |
| title_full_unstemmed | Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period |
| title_short | Viral Etiology of Chronic Obstructive Pulmonary Disease Exacerbations during the A/H1N1pdm09 Pandemic and Postpandemic Period |
| title_sort | viral etiology of chronic obstructive pulmonary disease exacerbations during the a h1n1pdm09 pandemic and postpandemic period |
| url | http://dx.doi.org/10.1155/2015/560679 |
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