Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials
PurposeThe Jianpi therapeutic strategy in traditional Chinese medicine aims to enhance the spleen’s digestive function and overall wellness. It has shown promise in improving cancer-related fatigue (CRF). This research systematically evaluates the effectiveness of Jianpi therapy in reducing fatigue...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1512460/full |
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| author | Jiaxing Dai Jiaxing Dai Huili Shui Huili Shui Huili Shui Yuan Wu Huanghui Zhang Huanghui Zhang Yuanyin Li Yuanyin Li Shaowang Zhang Shaowang Zhang Bing Yang Bing Yang Bing Yang Dongxin Tang Dongxin Tang Dongxin Tang |
| author_facet | Jiaxing Dai Jiaxing Dai Huili Shui Huili Shui Huili Shui Yuan Wu Huanghui Zhang Huanghui Zhang Yuanyin Li Yuanyin Li Shaowang Zhang Shaowang Zhang Bing Yang Bing Yang Bing Yang Dongxin Tang Dongxin Tang Dongxin Tang |
| author_sort | Jiaxing Dai |
| collection | DOAJ |
| description | PurposeThe Jianpi therapeutic strategy in traditional Chinese medicine aims to enhance the spleen’s digestive function and overall wellness. It has shown promise in improving cancer-related fatigue (CRF). This research systematically evaluates the effectiveness of Jianpi therapy in reducing fatigue in cancer patients through a meta-analytic review.MethodsAn exhaustive search was performed within PubMed, Embase, Web of Science, Cochrane Library, SinoMed, Wanfang Data, China Science and Technology Journal Database, and China National Knowledge Infrastructure (CNKI) for randomized controlled trials concerning the application of Jianpi therapy to address CRF. The search spanned from the commencement of each database’s records to April 1, 2024. The extracted data were subjected to analysis using Stata (Version 15.1), with the selection of either a random-effects or fixed-effects model based on the heterogeneity among studies. Outcome measures were demonstrated with standardized mean differences (SMDs) or mean differences (MDs), and each complemented by a 95% confidence interval (CI). The Cochrane Risk of Bias Assessment Tool 2.0 was utilized to assess the potential biases within the studies.ResultsA comprehensive analysis was performed on 45 eligible studies, all of which were conducted within China and encompassed a total of 3,596 participants. The meta-analysis indicated that Jianpi decoction alone exhibited the most significant improvement in the proportion of CD4 cells (SMD=1.34, 95% CI 0.54 to 2.31, P<0.001) and hemoglobin (MD=7.45, 95% CI 4.18 to 10.72, Z=4.47, P<0.001), while also more significantly reducing Piper Fatigue Scale scores (SMD=-2.05, 95% CI -2.71 to -1.39, P<0.001). The combined therapy, which integrated Jianpi therapy with standard care, demonstrated the greatest advantage in enhancing the proportion of CD3 cells (SMD=1.25, 95% CI 0.46 to 2.04, P<0.001). Furthermore, Jianpi therapy was found to be effective in lowering tumor necrosis factor-alpha levels (MD=-7.79, 95% CI -11.24 to -4.34, P<0.001) and concurrently enhancing interferon-gamma (MD=5.15, 95% CI 3.20 to 7.09, P=0.002), interleukin-2 (MD=8.37, 95% CI 6.14 to 10.59, P<0.001).ConclusionOur research indicates that Jianpi therapy effectively alleviates CRF, reduces inflammation, and strengthens immune function. However, further high-quality, multicenter randomized controlled trials are essential to confirm these findings and strengthen the evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024566739. |
| format | Article |
| id | doaj-art-0c53263155d44b4492673daa9ba360b8 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-0c53263155d44b4492673daa9ba360b82025-02-06T08:54:48ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15124601512460Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trialsJiaxing Dai0Jiaxing Dai1Huili Shui2Huili Shui3Huili Shui4Yuan Wu5Huanghui Zhang6Huanghui Zhang7Yuanyin Li8Yuanyin Li9Shaowang Zhang10Shaowang Zhang11Bing Yang12Bing Yang13Bing Yang14Dongxin Tang15Dongxin Tang16Dongxin Tang17The First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine (Guizhou Provincial Hospital of Chinese Medicine), Guiyang, ChinaThe Second Affiliated Hospital (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine (Guizhou Provincial Hospital of Chinese Medicine), Guiyang, ChinaThe First Clinical Medical School of Guizhou University of Chinese Medicine, Guiyang, ChinaTalent Base for TCM Tumor Inheritance and Science and Technology Innovation of Guizhou Province (Guizhou University of Chinese Medicine), Guiyang, ChinaThe First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine (Guizhou Provincial Hospital of Chinese Medicine), Guiyang, ChinaPurposeThe Jianpi therapeutic strategy in traditional Chinese medicine aims to enhance the spleen’s digestive function and overall wellness. It has shown promise in improving cancer-related fatigue (CRF). This research systematically evaluates the effectiveness of Jianpi therapy in reducing fatigue in cancer patients through a meta-analytic review.MethodsAn exhaustive search was performed within PubMed, Embase, Web of Science, Cochrane Library, SinoMed, Wanfang Data, China Science and Technology Journal Database, and China National Knowledge Infrastructure (CNKI) for randomized controlled trials concerning the application of Jianpi therapy to address CRF. The search spanned from the commencement of each database’s records to April 1, 2024. The extracted data were subjected to analysis using Stata (Version 15.1), with the selection of either a random-effects or fixed-effects model based on the heterogeneity among studies. Outcome measures were demonstrated with standardized mean differences (SMDs) or mean differences (MDs), and each complemented by a 95% confidence interval (CI). The Cochrane Risk of Bias Assessment Tool 2.0 was utilized to assess the potential biases within the studies.ResultsA comprehensive analysis was performed on 45 eligible studies, all of which were conducted within China and encompassed a total of 3,596 participants. The meta-analysis indicated that Jianpi decoction alone exhibited the most significant improvement in the proportion of CD4 cells (SMD=1.34, 95% CI 0.54 to 2.31, P<0.001) and hemoglobin (MD=7.45, 95% CI 4.18 to 10.72, Z=4.47, P<0.001), while also more significantly reducing Piper Fatigue Scale scores (SMD=-2.05, 95% CI -2.71 to -1.39, P<0.001). The combined therapy, which integrated Jianpi therapy with standard care, demonstrated the greatest advantage in enhancing the proportion of CD3 cells (SMD=1.25, 95% CI 0.46 to 2.04, P<0.001). Furthermore, Jianpi therapy was found to be effective in lowering tumor necrosis factor-alpha levels (MD=-7.79, 95% CI -11.24 to -4.34, P<0.001) and concurrently enhancing interferon-gamma (MD=5.15, 95% CI 3.20 to 7.09, P=0.002), interleukin-2 (MD=8.37, 95% CI 6.14 to 10.59, P<0.001).ConclusionOur research indicates that Jianpi therapy effectively alleviates CRF, reduces inflammation, and strengthens immune function. However, further high-quality, multicenter randomized controlled trials are essential to confirm these findings and strengthen the evidence.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024566739.https://www.frontiersin.org/articles/10.3389/fonc.2025.1512460/fullJianpitraditional Chinese medicinecancer-related fatiguerandomized controlled trialsmeta-analysis |
| spellingShingle | Jiaxing Dai Jiaxing Dai Huili Shui Huili Shui Huili Shui Yuan Wu Huanghui Zhang Huanghui Zhang Yuanyin Li Yuanyin Li Shaowang Zhang Shaowang Zhang Bing Yang Bing Yang Bing Yang Dongxin Tang Dongxin Tang Dongxin Tang Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials Frontiers in Oncology Jianpi traditional Chinese medicine cancer-related fatigue randomized controlled trials meta-analysis |
| title | Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials |
| title_full | Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials |
| title_fullStr | Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials |
| title_full_unstemmed | Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials |
| title_short | Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials |
| title_sort | effects of jianpi therapy for cancer related fatigue a meta analysis of randomized controlled trials |
| topic | Jianpi traditional Chinese medicine cancer-related fatigue randomized controlled trials meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1512460/full |
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