Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus
In many areas, antibiotic resistance is becoming a serious concern for public health. As a result of the interesting structural properties of nanomaterials, nanoscience-based methods have emerged as promising ways to increase the movement of existing antimicrobials. In this study, pristine nickel ox...
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221171562400643X |
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| author | Ali Shakerimoghaddam Hayder Jihad Majeed Ali Jawad Hashim May Jaleel Abed Layth S. Jasim Masoud Salavati-Niasari |
| author_facet | Ali Shakerimoghaddam Hayder Jihad Majeed Ali Jawad Hashim May Jaleel Abed Layth S. Jasim Masoud Salavati-Niasari |
| author_sort | Ali Shakerimoghaddam |
| collection | DOAJ |
| description | In many areas, antibiotic resistance is becoming a serious concern for public health. As a result of the interesting structural properties of nanomaterials, nanoscience-based methods have emerged as promising ways to increase the movement of existing antimicrobials. In this study, pristine nickel oxide (NiO) nanoparticles, hydroxyapatite (HAP) nanoparticles, and binary nickel oxide/hydroxyapatite (NiO/HAP) nanocomposites were fabricated through peppermint extract-assisted green route. The obtained results revealed that peppermint extract can be a superior green capping agent for the preparation of NiO, HAP, and NiO/HAP nanomaterials. The bioactivity tests revealed the bactericidal and anti-biofilm activities of synthesized NiO, HAP, and NiO/HAP nanostructures against Pseudomonas aeruginosa (PAO1) and Staphylococcus aureus (ATCC 43300) bacteria. The findings confirmed that the prepared NiO/HAP nanocomposites have more effective antibacterial activity than pure NiO and HAP. For Staphylococcus aureus, the minimal inhibitory concentration (MIC) values for NiO, HAP, and NiO/HAP nanocomposites were determined to be of about 9.60, 13.03, and 3.41 mg/mL, respectively. For Pseudomonas aeruginosa, the MIC values for NiO, HAP, and NiO/HAP nanocomposites were estimated as 9.6, 13.50, and 1.7 mg/mL, respectively. Although, all synthesized samples are remarkable in their ability to prevent the formation of biofilms at MIC and sub-MIC concentrations (p < 0.01), NiO/HAP illustrated biofilm inhibitory activity up to 95 % for Pseudomonas aeruginosa and to 81 % for Staphylococcus aureus. In the present study, it was demonstrated that NiO/HAP nanocomposites prepared in a green environment can be excellent antibacterial agents against Staphylococcus aureus and Pseudomonas aeruginosa. |
| format | Article |
| id | doaj-art-0c2e3d4b19304ff9a5024a1cb37b7000 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-0c2e3d4b19304ff9a5024a1cb37b70002025-01-29T05:00:39ZengElsevierResults in Chemistry2211-71562025-01-0113101947Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureusAli Shakerimoghaddam0Hayder Jihad Majeed1Ali Jawad Hashim2May Jaleel Abed3Layth S. Jasim4Masoud Salavati-Niasari5Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, IranMinistry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, IraqMinistry of Education General Directorate of Al-Qadisiyah Education, Diwaniyah, IraqDepartment of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, IraqDepartment of Chemistry, College of Education, University of Al-Qadisiyah, Diwaniyah, IraqInstitute of Nano Science and Nano Technology, University of Kashan, P. O. Box. 87317-51167, Kashan, Iran; Corresponding author.In many areas, antibiotic resistance is becoming a serious concern for public health. As a result of the interesting structural properties of nanomaterials, nanoscience-based methods have emerged as promising ways to increase the movement of existing antimicrobials. In this study, pristine nickel oxide (NiO) nanoparticles, hydroxyapatite (HAP) nanoparticles, and binary nickel oxide/hydroxyapatite (NiO/HAP) nanocomposites were fabricated through peppermint extract-assisted green route. The obtained results revealed that peppermint extract can be a superior green capping agent for the preparation of NiO, HAP, and NiO/HAP nanomaterials. The bioactivity tests revealed the bactericidal and anti-biofilm activities of synthesized NiO, HAP, and NiO/HAP nanostructures against Pseudomonas aeruginosa (PAO1) and Staphylococcus aureus (ATCC 43300) bacteria. The findings confirmed that the prepared NiO/HAP nanocomposites have more effective antibacterial activity than pure NiO and HAP. For Staphylococcus aureus, the minimal inhibitory concentration (MIC) values for NiO, HAP, and NiO/HAP nanocomposites were determined to be of about 9.60, 13.03, and 3.41 mg/mL, respectively. For Pseudomonas aeruginosa, the MIC values for NiO, HAP, and NiO/HAP nanocomposites were estimated as 9.6, 13.50, and 1.7 mg/mL, respectively. Although, all synthesized samples are remarkable in their ability to prevent the formation of biofilms at MIC and sub-MIC concentrations (p < 0.01), NiO/HAP illustrated biofilm inhibitory activity up to 95 % for Pseudomonas aeruginosa and to 81 % for Staphylococcus aureus. In the present study, it was demonstrated that NiO/HAP nanocomposites prepared in a green environment can be excellent antibacterial agents against Staphylococcus aureus and Pseudomonas aeruginosa.http://www.sciencedirect.com/science/article/pii/S221171562400643XNiO/Hydroxyapatite nanocompositesNanostructuresBiofilmAntibacterial propertyGreen synthesisMIC |
| spellingShingle | Ali Shakerimoghaddam Hayder Jihad Majeed Ali Jawad Hashim May Jaleel Abed Layth S. Jasim Masoud Salavati-Niasari Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus Results in Chemistry NiO/Hydroxyapatite nanocomposites Nanostructures Biofilm Antibacterial property Green synthesis MIC |
| title | Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus |
| title_full | Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus |
| title_fullStr | Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus |
| title_full_unstemmed | Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus |
| title_short | Green synthesis and characterization of NiO/Hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against Pseudomonas aeruginosa and Staphylococcus aureus |
| title_sort | green synthesis and characterization of nio hydroxyapatite nanocomposites in the presence of peppermint extract and investigation of their antibacterial activities against pseudomonas aeruginosa and staphylococcus aureus |
| topic | NiO/Hydroxyapatite nanocomposites Nanostructures Biofilm Antibacterial property Green synthesis MIC |
| url | http://www.sciencedirect.com/science/article/pii/S221171562400643X |
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