Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia
We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with tolui...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2011/269491 |
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| author | Alicia Rojas-Atencio Karelis Urdaneta Marisol Soto-Quintana Francisco Alvarez Nava Jenny Cañizales Ernesto Solis |
| author_facet | Alicia Rojas-Atencio Karelis Urdaneta Marisol Soto-Quintana Francisco Alvarez Nava Jenny Cañizales Ernesto Solis |
| author_sort | Alicia Rojas-Atencio |
| collection | DOAJ |
| description | We report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22). |
| format | Article |
| id | doaj-art-0c1f92c77bbb4b0b904d0da7b14d444c |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-0c1f92c77bbb4b0b904d0da7b14d444c2025-08-20T02:02:55ZengWileyCase Reports in Pathology2090-67812090-679X2011-01-01201110.1155/2011/269491269491Trisomy 19 and T(9;22) In a Patient with Acute Basophilic LeukemiaAlicia Rojas-Atencio0Karelis Urdaneta1Marisol Soto-Quintana2Francisco Alvarez Nava3Jenny Cañizales4Ernesto Solis5Genetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaGenetic Medical Unity, Faculty of Medicine, University of Zulia, Maracaibo, VenezuelaWe report a case of acute basophilic leukemia with two coexisting clonal abnormalities, t(9;22) and trisomy 19. The blast showed positive reaction with myeloperoxidase but negative reaction with chloroacetate esterase and acid phosphatase. Metachromatic features of the blast were observed with toluidine blue stain. Ultrastructure study showed the presence of azurophilic granules in basophils and blast mast cells. Conventional and molecular cytogenetic studies revealed, t(9;22) with BCR/ABL positive and trisomy 19 in all metaphase cells. To our knowledge, this paper here is the first to present acute basophilic leukemia with trisomy 19 and t(9;22).http://dx.doi.org/10.1155/2011/269491 |
| spellingShingle | Alicia Rojas-Atencio Karelis Urdaneta Marisol Soto-Quintana Francisco Alvarez Nava Jenny Cañizales Ernesto Solis Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia Case Reports in Pathology |
| title | Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia |
| title_full | Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia |
| title_fullStr | Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia |
| title_full_unstemmed | Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia |
| title_short | Trisomy 19 and T(9;22) In a Patient with Acute Basophilic Leukemia |
| title_sort | trisomy 19 and t 9 22 in a patient with acute basophilic leukemia |
| url | http://dx.doi.org/10.1155/2011/269491 |
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