Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach
Abstract Background Oral function tests have been shown to reliably detect impaired bulbar function in adults with spinal muscular atrophy (SMA). Although not routinely recorded, it is known that persons with SMA are affected to varying degrees. Detecting differences in bite and tongue force, endura...
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BMC
2024-10-01
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| Series: | Orphanet Journal of Rare Diseases |
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| Online Access: | https://doi.org/10.1186/s13023-024-03405-5 |
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| author | Teresa Kruse Diana Leflerovà Annette Cap Sara Portegys Brunhilde Wirth Raoul Heller Svenja Brakemeier Tim Hagenacker Bert Braumann Gilbert Wunderlich |
| author_facet | Teresa Kruse Diana Leflerovà Annette Cap Sara Portegys Brunhilde Wirth Raoul Heller Svenja Brakemeier Tim Hagenacker Bert Braumann Gilbert Wunderlich |
| author_sort | Teresa Kruse |
| collection | DOAJ |
| description | Abstract Background Oral function tests have been shown to reliably detect impaired bulbar function in adults with spinal muscular atrophy (SMA). Although not routinely recorded, it is known that persons with SMA are affected to varying degrees. Detecting differences in bite and tongue force, endurance, and maximum mouth opening has become particularly promising since the introduction of causal therapy for SMA. This study aimed to compare oral function among adult persons with SMA with different SMA types, walking abilities, and treatment status to a healthy control group. Methods Data from oral function tests conducted on 58 persons with SMA and 45 healthy individuals were analyzed. Differences in oral function between SMA subgroups were pairwise tested and compared to the healthy control group using Wilcoxon rank sum tests. Results In an overall comparison, three out of five oral function tests revealed lower values for the SMA group compared to the control group. Subgroup analyses indicated lower scores for most oral function tests in non-ambulatory, untreated patients with SMA type 2 compared to controls. Ambulatory, treated patients with SMA type 3 achieved strength and endurance values comparable to those of healthy individuals. Conclusions The impairment of oral function varies across persons with SMA. Routine measurement of oral function is warranted to determine individual bulbar involvement stages. Further evaluation should be scheduled if indicators such as restricted maximum mouth opening arise. Trial registration DRKS, DRKS00015842. Registered 30 July 2019, https://drks.de/register/de/trial/DRKS00015842/preview . |
| format | Article |
| id | doaj-art-0c1f50b5ca4e4349a1a7637cf38d9de1 |
| institution | OA Journals |
| issn | 1750-1172 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | BMC |
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| series | Orphanet Journal of Rare Diseases |
| spelling | doaj-art-0c1f50b5ca4e4349a1a7637cf38d9de12025-08-20T02:17:48ZengBMCOrphanet Journal of Rare Diseases1750-11722024-10-0119111310.1186/s13023-024-03405-5Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approachTeresa Kruse0Diana Leflerovà1Annette Cap2Sara Portegys3Brunhilde Wirth4Raoul Heller5Svenja Brakemeier6Tim Hagenacker7Bert Braumann8Gilbert Wunderlich9Department of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital EssenDepartment of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital EssenDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneDepartment of Orthodontics, Faculty of Medicine and University Hospital Cologne, University of CologneAbstract Background Oral function tests have been shown to reliably detect impaired bulbar function in adults with spinal muscular atrophy (SMA). Although not routinely recorded, it is known that persons with SMA are affected to varying degrees. Detecting differences in bite and tongue force, endurance, and maximum mouth opening has become particularly promising since the introduction of causal therapy for SMA. This study aimed to compare oral function among adult persons with SMA with different SMA types, walking abilities, and treatment status to a healthy control group. Methods Data from oral function tests conducted on 58 persons with SMA and 45 healthy individuals were analyzed. Differences in oral function between SMA subgroups were pairwise tested and compared to the healthy control group using Wilcoxon rank sum tests. Results In an overall comparison, three out of five oral function tests revealed lower values for the SMA group compared to the control group. Subgroup analyses indicated lower scores for most oral function tests in non-ambulatory, untreated patients with SMA type 2 compared to controls. Ambulatory, treated patients with SMA type 3 achieved strength and endurance values comparable to those of healthy individuals. Conclusions The impairment of oral function varies across persons with SMA. Routine measurement of oral function is warranted to determine individual bulbar involvement stages. Further evaluation should be scheduled if indicators such as restricted maximum mouth opening arise. Trial registration DRKS, DRKS00015842. Registered 30 July 2019, https://drks.de/register/de/trial/DRKS00015842/preview .https://doi.org/10.1186/s13023-024-03405-5Spinal muscular atrophyBulbar neuromuscular functionOutcome measuresBite forceTongue pressureEndurance |
| spellingShingle | Teresa Kruse Diana Leflerovà Annette Cap Sara Portegys Brunhilde Wirth Raoul Heller Svenja Brakemeier Tim Hagenacker Bert Braumann Gilbert Wunderlich Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach Orphanet Journal of Rare Diseases Spinal muscular atrophy Bulbar neuromuscular function Outcome measures Bite force Tongue pressure Endurance |
| title | Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach |
| title_full | Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach |
| title_fullStr | Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach |
| title_full_unstemmed | Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach |
| title_short | Oral functions in adult persons with spinal muscular atrophy compared to a healthy control group: a prospective cross-sectional study with a multimodal approach |
| title_sort | oral functions in adult persons with spinal muscular atrophy compared to a healthy control group a prospective cross sectional study with a multimodal approach |
| topic | Spinal muscular atrophy Bulbar neuromuscular function Outcome measures Bite force Tongue pressure Endurance |
| url | https://doi.org/10.1186/s13023-024-03405-5 |
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