Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence
The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidat...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2015/954120 |
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| author | Shan Geng Xin-Yi Mu Xiong-Bin Chen Ji-Ying Hou Dao-Yong Jia Chun-Yan Xu Ya-Ping Wang |
| author_facet | Shan Geng Xin-Yi Mu Xiong-Bin Chen Ji-Ying Hou Dao-Yong Jia Chun-Yan Xu Ya-Ping Wang |
| author_sort | Shan Geng |
| collection | DOAJ |
| description | The researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidation ability. In accordance with that, the senescence of HSPCs also started from the middle age, since the self-renewal and differentiation ability remarkably decreased, and senescence-associated markers SA-β-GAL increased in the 6-month-old and the older groups. Interestingly, the telomere length and telomerase activity increased to a certain degree in the 6-month-old group. It suggested an intrinsic spontaneous ability of HSPCs against aging. It may provide a theoretical and experimental foundation for better understanding the senescence progress of HSPCs. And the dynamic biological characteristics of HSPCs senescence may also contribute to the clinical optimal time for antiaging drug intervention. |
| format | Article |
| id | doaj-art-0c19f2beb6b84df5a34c0b3a5a931cf5 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0c19f2beb6b84df5a34c0b3a5a931cf52025-02-03T06:44:37ZengWileyStem Cells International1687-966X1687-96782015-01-01201510.1155/2015/954120954120Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell SenescenceShan Geng0Xin-Yi Mu1Xiong-Bin Chen2Ji-Ying Hou3Dao-Yong Jia4Chun-Yan Xu5Ya-Ping Wang6Laboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, ChinaChongqing Medical University, Chongqing 400016, ChinaChongqing Medical University, Chongqing 400016, ChinaChongqing Medical University, Chongqing 400016, ChinaChongqing Medical University, Chongqing 400016, ChinaChongqing Medical University, Chongqing 400016, ChinaLaboratory of Stem Cells and Tissue Engineering, Department of Histology and Embryology, Chongqing Medical University, Chongqing 400016, ChinaThe researches in the dynamic changes of the progress of HSCs aging are very limited and necessary. In this study, male C57BL/6 mice were divided into 5 groups by age. We found that the superoxide damage of HSPCs started to increase from the middle age (6 months old), with notably reduced antioxidation ability. In accordance with that, the senescence of HSPCs also started from the middle age, since the self-renewal and differentiation ability remarkably decreased, and senescence-associated markers SA-β-GAL increased in the 6-month-old and the older groups. Interestingly, the telomere length and telomerase activity increased to a certain degree in the 6-month-old group. It suggested an intrinsic spontaneous ability of HSPCs against aging. It may provide a theoretical and experimental foundation for better understanding the senescence progress of HSPCs. And the dynamic biological characteristics of HSPCs senescence may also contribute to the clinical optimal time for antiaging drug intervention.http://dx.doi.org/10.1155/2015/954120 |
| spellingShingle | Shan Geng Xin-Yi Mu Xiong-Bin Chen Ji-Ying Hou Dao-Yong Jia Chun-Yan Xu Ya-Ping Wang Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence Stem Cells International |
| title | Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence |
| title_full | Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence |
| title_fullStr | Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence |
| title_full_unstemmed | Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence |
| title_short | Study on the Dynamic Biological Characteristics of Sca-1+ Hematopoietic Stem and Progenitor Cell Senescence |
| title_sort | study on the dynamic biological characteristics of sca 1 hematopoietic stem and progenitor cell senescence |
| url | http://dx.doi.org/10.1155/2015/954120 |
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