Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer
Introduction: Coronary artery calcification (CAC) is a well-known cardiovascular risk factor. In the past year, the CAC score has been investigated in lung cancer (LC) screening, suggesting promising results in terms of mortality risk assessment. Nevertheless, its role in patients with LC is still t...
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Elsevier
2025-03-01
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| Series: | JTO Clinical and Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666364325000049 |
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| author | Federica Sabia, MSc Camilla Valsecchi, MSc Roberta Eufrasia Ledda, MD Giorgio Bogani, MD Riccardo Orlandi, MD Luigi Rolli, MD Michele Ferrari, MD Maurizio Balbi, MD Alfonso Marchianò, MD Ugo Pastorino, MD |
| author_facet | Federica Sabia, MSc Camilla Valsecchi, MSc Roberta Eufrasia Ledda, MD Giorgio Bogani, MD Riccardo Orlandi, MD Luigi Rolli, MD Michele Ferrari, MD Maurizio Balbi, MD Alfonso Marchianò, MD Ugo Pastorino, MD |
| author_sort | Federica Sabia, MSc |
| collection | DOAJ |
| description | Introduction: Coronary artery calcification (CAC) is a well-known cardiovascular risk factor. In the past year, the CAC score has been investigated in lung cancer (LC) screening, suggesting promising results in terms of mortality risk assessment. Nevertheless, its role in patients with LC is still to be investigated. This study aimed to evaluate the performance of a fully automated CAC scoring alone and combined with a prognostic index on the basis of perioperative routine blood tests in predicting 5-year survival of patients with stage I LC. Methods: This study included 536 consecutive patients with stage I LC who underwent preoperative chest computed tomography followed by surgical resection. The CAC score was measured by commercially available, fully automated artificial intelligence software. The primary outcome was the 5-year overall survival rate. Results: A total of 110 patients (20.5%) had a CAC score greater than or equal to 400, 149 (27.8%) between 100 and 399, and 277 (51.7%) had less than 100. Male smokers had the highest CAC values: 32% compared with only 17% of nonsmokers. Females had lower CAC values compared with males both in smokers and nonsmokers: CAC greater than or equal to 400 only for 10% of smoking females and 0% in nonsmoking females. The 5-year survival was 80.3% overall, 84.7% in CAC less than 100, 77.5% in CAC 100 to 399, and 73.5% in CAC greater than or equal to 400 (p = 0.0047). Conclusions: We observed that the CAC score predicted the 5-year overall survival in patients with resected stage I LC, both alone and combined with the modified routine blood test score. These results open new prospects for the prevention of noncancer mortality in patients with early-stage LC. |
| format | Article |
| id | doaj-art-0c190b592eec4293ba66614be1e7ccd8 |
| institution | Kabale University |
| issn | 2666-3643 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JTO Clinical and Research Reports |
| spelling | doaj-art-0c190b592eec4293ba66614be1e7ccd82025-02-05T04:32:40ZengElsevierJTO Clinical and Research Reports2666-36432025-03-0163100788Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung CancerFederica Sabia, MSc0Camilla Valsecchi, MSc1Roberta Eufrasia Ledda, MD2Giorgio Bogani, MD3Riccardo Orlandi, MD4Luigi Rolli, MD5Michele Ferrari, MD6Maurizio Balbi, MD7Alfonso Marchianò, MD8Ugo Pastorino, MD9Division of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, ItalyDivision of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, ItalyDivision of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy; Section of Radiology, Department of Medicine and Surgery (DiMeC), University Hospital of Parma, Parma, ItalyDepartment of Gynecologic Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, ItalyDepartment of Thoracic Surgery, University of Milan, Milan, ItalyDivision of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, ItalyDivision of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, ItalyRadiology Unit, Department of Oncology, San Luigi Gonzaga Hospital, University of Turin, Orbassano, ItalyDepartment of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, ItalyDivision of Thoracic Surgery, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Nazionale dei Tumori, Milan, Italy; Corresponding author. Address for correspondence: Ugo Pastorino, MD, Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy.Introduction: Coronary artery calcification (CAC) is a well-known cardiovascular risk factor. In the past year, the CAC score has been investigated in lung cancer (LC) screening, suggesting promising results in terms of mortality risk assessment. Nevertheless, its role in patients with LC is still to be investigated. This study aimed to evaluate the performance of a fully automated CAC scoring alone and combined with a prognostic index on the basis of perioperative routine blood tests in predicting 5-year survival of patients with stage I LC. Methods: This study included 536 consecutive patients with stage I LC who underwent preoperative chest computed tomography followed by surgical resection. The CAC score was measured by commercially available, fully automated artificial intelligence software. The primary outcome was the 5-year overall survival rate. Results: A total of 110 patients (20.5%) had a CAC score greater than or equal to 400, 149 (27.8%) between 100 and 399, and 277 (51.7%) had less than 100. Male smokers had the highest CAC values: 32% compared with only 17% of nonsmokers. Females had lower CAC values compared with males both in smokers and nonsmokers: CAC greater than or equal to 400 only for 10% of smoking females and 0% in nonsmoking females. The 5-year survival was 80.3% overall, 84.7% in CAC less than 100, 77.5% in CAC 100 to 399, and 73.5% in CAC greater than or equal to 400 (p = 0.0047). Conclusions: We observed that the CAC score predicted the 5-year overall survival in patients with resected stage I LC, both alone and combined with the modified routine blood test score. These results open new prospects for the prevention of noncancer mortality in patients with early-stage LC.http://www.sciencedirect.com/science/article/pii/S2666364325000049Stage I lung cancerCoronary artery calcificationRoutine blood testsArtificial intelligence |
| spellingShingle | Federica Sabia, MSc Camilla Valsecchi, MSc Roberta Eufrasia Ledda, MD Giorgio Bogani, MD Riccardo Orlandi, MD Luigi Rolli, MD Michele Ferrari, MD Maurizio Balbi, MD Alfonso Marchianò, MD Ugo Pastorino, MD Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer JTO Clinical and Research Reports Stage I lung cancer Coronary artery calcification Routine blood tests Artificial intelligence |
| title | Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer |
| title_full | Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer |
| title_fullStr | Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer |
| title_full_unstemmed | Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer |
| title_short | Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer |
| title_sort | automated measurement of coronary artery calcifications and routine perioperative blood tests predict survival in resected stage i lung cancer |
| topic | Stage I lung cancer Coronary artery calcification Routine blood tests Artificial intelligence |
| url | http://www.sciencedirect.com/science/article/pii/S2666364325000049 |
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