Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy
Background. Intraoperative fluid (IOF) administration plays an important role during major abdominal surgery although increased fluid intake can adversely influence postoperative outcomes. However, the effect of the IOF rate on the outcomes of pancreatoduodenectomy (PD) is unclear. Methods. 151 pati...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/8914367 |
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| author | Xuefeng Cao Xixiu Wang Baolei Zhao Lingqun Kong Lei Zhou Wentao Zhu Xutao Lin Qiangpu Chen Xingyuan Zhang |
| author_facet | Xuefeng Cao Xixiu Wang Baolei Zhao Lingqun Kong Lei Zhou Wentao Zhu Xutao Lin Qiangpu Chen Xingyuan Zhang |
| author_sort | Xuefeng Cao |
| collection | DOAJ |
| description | Background. Intraoperative fluid (IOF) administration plays an important role during major abdominal surgery although increased fluid intake can adversely influence postoperative outcomes. However, the effect of the IOF rate on the outcomes of pancreatoduodenectomy (PD) is unclear. Methods. 151 patients, who underwent PD at Binzhou Medical University Hospital between January 2010 and May 2017, were categorized into three groups according to IOF rates (ml/kg/hr): restricted (<10, n=47), standard (10–15, n=76), and liberal (>15, n=28). Results. The overall postoperative morbidity was 56.95%. The incidence of postoperative pancreatic fistula (POPF) was 11.26%. The in-hospital mortality rate was 7.28% with the most common cause being grade C POPF and secondary intra-abdominal infections. The patients in the liberal group had significantly higher incidences of POPF (25%) and respiratory complications (21.43%). The other outcome parameters such as recovery of bowel function, hospital stay, and postoperative daily drainage were similar among the groups. Multivariable analysis confirmed the IOF rate to be most strongly associated with POPF (odds ratio: 5.195, confidence interval: 1.142–23.823, P=0.023) and respiratory complications (odds ratio: 7.302, confidence interval: 0.676–58.231, P=0.025). Conclusions. The IOF rate significantly affects the incidence of POPF and respiratory complications after PD. Careful patient-oriented fluid therapy may help to prevent these complications. |
| format | Article |
| id | doaj-art-0c14614a05714759a5d3bf8f6143af1a |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0c14614a05714759a5d3bf8f6143af1a2025-02-03T00:58:48ZengWileyGastroenterology Research and Practice1687-61211687-630X2020-01-01202010.1155/2020/89143678914367Correlation between Intraoperative Fluid Administration and Outcomes of PancreatoduodenectomyXuefeng Cao0Xixiu Wang1Baolei Zhao2Lingqun Kong3Lei Zhou4Wentao Zhu5Xutao Lin6Qiangpu Chen7Xingyuan Zhang8Department of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Cardiovascular Medicine, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaDepartment of Hepatobiliary Surgery, Binzhou Medical University Hospital, Binzhou, Shandong Province, ChinaBackground. Intraoperative fluid (IOF) administration plays an important role during major abdominal surgery although increased fluid intake can adversely influence postoperative outcomes. However, the effect of the IOF rate on the outcomes of pancreatoduodenectomy (PD) is unclear. Methods. 151 patients, who underwent PD at Binzhou Medical University Hospital between January 2010 and May 2017, were categorized into three groups according to IOF rates (ml/kg/hr): restricted (<10, n=47), standard (10–15, n=76), and liberal (>15, n=28). Results. The overall postoperative morbidity was 56.95%. The incidence of postoperative pancreatic fistula (POPF) was 11.26%. The in-hospital mortality rate was 7.28% with the most common cause being grade C POPF and secondary intra-abdominal infections. The patients in the liberal group had significantly higher incidences of POPF (25%) and respiratory complications (21.43%). The other outcome parameters such as recovery of bowel function, hospital stay, and postoperative daily drainage were similar among the groups. Multivariable analysis confirmed the IOF rate to be most strongly associated with POPF (odds ratio: 5.195, confidence interval: 1.142–23.823, P=0.023) and respiratory complications (odds ratio: 7.302, confidence interval: 0.676–58.231, P=0.025). Conclusions. The IOF rate significantly affects the incidence of POPF and respiratory complications after PD. Careful patient-oriented fluid therapy may help to prevent these complications.http://dx.doi.org/10.1155/2020/8914367 |
| spellingShingle | Xuefeng Cao Xixiu Wang Baolei Zhao Lingqun Kong Lei Zhou Wentao Zhu Xutao Lin Qiangpu Chen Xingyuan Zhang Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy Gastroenterology Research and Practice |
| title | Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy |
| title_full | Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy |
| title_fullStr | Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy |
| title_full_unstemmed | Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy |
| title_short | Correlation between Intraoperative Fluid Administration and Outcomes of Pancreatoduodenectomy |
| title_sort | correlation between intraoperative fluid administration and outcomes of pancreatoduodenectomy |
| url | http://dx.doi.org/10.1155/2020/8914367 |
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