Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure
Background. Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associ...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/1575410 |
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| author | Jing Ye Zhen Wang Di Ye Yuan Wang Menglong Wang Qingwei Ji Ying Huang Ling Liu Ying Shi Lei Shi Tao Zeng Yao Xu Jianfang Liu Huimin Jiang Yingzhong Lin Jun Wan |
| author_facet | Jing Ye Zhen Wang Di Ye Yuan Wang Menglong Wang Qingwei Ji Ying Huang Ling Liu Ying Shi Lei Shi Tao Zeng Yao Xu Jianfang Liu Huimin Jiang Yingzhong Lin Jun Wan |
| author_sort | Jing Ye |
| collection | DOAJ |
| description | Background. Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associated with the cardiac prognosis in patients with HF. Methods. The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. In addition, we prospectively followed these CHF patients to endpoints of cardiac events. Results. Compared with the control group, the plasma IL-11 concentrations were significantly increased in the CHF patients and gradually increased in the New York Heart Association (NYHA) functional class II group, the NYHA functional class III group, and the NYHA functional class IV group. The receiver operating characteristic (ROC) curve revealed that the predictive role of IL-11 in HF is not as good as N-terminal B-type natriuretic peptide (BNP), although IL-11 has a certain value in predicting cardiac events. In addition, the CHF patients were divided into 3 groups according to the plasma IL-11 concentration category (low, T1; middle, T2; and high, T3). The multivariate Cox hazard analysis showed that the high plasma IL-11 concentrations were independently associated with the presence of cardiac events after adjustment for confounding factors. Furthermore, the CHF patients were divided into two groups based on the median plasma IL-11 concentrations. The Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations had a higher risk of cardiac events compared with those with low IL-11 concentrations. Conclusions. Higher plasma IL-11 levels significantly increase the presence of cardiac events and suggest a poor outcome; although the diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value in predicting cardiac events in CHF. |
| format | Article |
| id | doaj-art-0c12b5699c334491be9a83f2a91ae595 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0c12b5699c334491be9a83f2a91ae5952025-02-03T05:50:51ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/15754101575410Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart FailureJing Ye0Zhen Wang1Di Ye2Yuan Wang3Menglong Wang4Qingwei Ji5Ying Huang6Ling Liu7Ying Shi8Lei Shi9Tao Zeng10Yao Xu11Jianfang Liu12Huimin Jiang13Yingzhong Lin14Jun Wan15Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University, Hubei Key Laboratory of Cardiology, Wuhan 430060, ChinaBackground. Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have been no studies about the role of IL-11 in heart failure (HF). The present study is aimed at investigating whether IL-11 levels are associated with the cardiac prognosis in patients with HF. Methods. The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. In addition, we prospectively followed these CHF patients to endpoints of cardiac events. Results. Compared with the control group, the plasma IL-11 concentrations were significantly increased in the CHF patients and gradually increased in the New York Heart Association (NYHA) functional class II group, the NYHA functional class III group, and the NYHA functional class IV group. The receiver operating characteristic (ROC) curve revealed that the predictive role of IL-11 in HF is not as good as N-terminal B-type natriuretic peptide (BNP), although IL-11 has a certain value in predicting cardiac events. In addition, the CHF patients were divided into 3 groups according to the plasma IL-11 concentration category (low, T1; middle, T2; and high, T3). The multivariate Cox hazard analysis showed that the high plasma IL-11 concentrations were independently associated with the presence of cardiac events after adjustment for confounding factors. Furthermore, the CHF patients were divided into two groups based on the median plasma IL-11 concentrations. The Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations had a higher risk of cardiac events compared with those with low IL-11 concentrations. Conclusions. Higher plasma IL-11 levels significantly increase the presence of cardiac events and suggest a poor outcome; although the diagnostic value of IL-11 in CHF is not as good as BNP, there is a certain value in predicting cardiac events in CHF.http://dx.doi.org/10.1155/2019/1575410 |
| spellingShingle | Jing Ye Zhen Wang Di Ye Yuan Wang Menglong Wang Qingwei Ji Ying Huang Ling Liu Ying Shi Lei Shi Tao Zeng Yao Xu Jianfang Liu Huimin Jiang Yingzhong Lin Jun Wan Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure Mediators of Inflammation |
| title | Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure |
| title_full | Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure |
| title_fullStr | Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure |
| title_full_unstemmed | Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure |
| title_short | Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure |
| title_sort | increased interleukin 11 levels are correlated with cardiac events in patients with chronic heart failure |
| url | http://dx.doi.org/10.1155/2019/1575410 |
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