SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire

During thymic development, most γδ T cells acquire innate-like characteristics that are critical for their function in tumor surveillance, infectious disease, and tissue repair. The mechanisms, however, that regulate γδ T cell developmental programming remain unclear. Recently, we demonstrated that...

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Bibliographic Details
Main Authors: Somen K Mistri, Brianna M Hilton, Katherine J Horrigan, Emma S Andretta, Remi Savard, Oliver Dienz, Kenneth J Hampel, Diana L Gerrard, Joshua T Rose, Nikoletta Sidiropoulos, Dev Majumdar, Jonathan E Boyson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
gamma delta T cells
T cells
thymic development
Online Access:https://elifesciences.org/articles/97229
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