Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases
The interplay between energy metabolism and the gut barrier is crucial for maintaining intestinal physiological homeostasis. Energy metabolism and the intestinal barrier perform distinct yet complementary roles that uphold intestinal ecological equilibrium. Disruptions in energy metabolism can compr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515364/full |
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| author | Shuai Chen Caifei Shen Xiaorui Zeng Luqiang Sun Fangli Luo Renhong Wan Yupeng Zhang Xinyun Chen Yujun Hou Wen Wang Qianhua Zheng Ying Li |
| author_facet | Shuai Chen Caifei Shen Xiaorui Zeng Luqiang Sun Fangli Luo Renhong Wan Yupeng Zhang Xinyun Chen Yujun Hou Wen Wang Qianhua Zheng Ying Li |
| author_sort | Shuai Chen |
| collection | DOAJ |
| description | The interplay between energy metabolism and the gut barrier is crucial for maintaining intestinal physiological homeostasis. Energy metabolism and the intestinal barrier perform distinct yet complementary roles that uphold intestinal ecological equilibrium. Disruptions in energy metabolism can compromise the integrity of the intestinal barrier; for example, inactivation of the AMPK pathway may lead to reduced expression of proteins associated with tight junctions. Conversely, impairment of the intestinal barrier can result in metabolic dysregulation, such as alterations in the gut microbiota that impede the production of short-chain fatty acids (SCFAs), which are essential substrates for energy metabolism. This disruption can affect energy production and modify the gut’s hypoxic environment. Imbalances in these systems have been associated with the onset of various intestinal diseases. Research indicates that dietary interventions, such as a low FODMAP diet, can enhance the colonization of probiotics and improve the fermentation metabolism of SCFAs. Pharmacological strategies to elevate SCFA levels can activate the AMPK pathway and rectify abnormalities in energy metabolism. This review provides a comprehensive summary of recent advancements in elucidating the interactions between energy metabolism and the intestinal barrier. |
| format | Article |
| id | doaj-art-0c06929c3c4f44b1855326cbc443390d |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-0c06929c3c4f44b1855326cbc443390d2025-01-31T09:05:16ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-01-011610.3389/fmicb.2025.15153641515364Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseasesShuai Chen0Caifei Shen1Xiaorui Zeng2Luqiang Sun3Fangli Luo4Renhong Wan5Yupeng Zhang6Xinyun Chen7Yujun Hou8Wen Wang9Qianhua Zheng10Ying Li11Acupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaAcupuncture and Tuina College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaThe interplay between energy metabolism and the gut barrier is crucial for maintaining intestinal physiological homeostasis. Energy metabolism and the intestinal barrier perform distinct yet complementary roles that uphold intestinal ecological equilibrium. Disruptions in energy metabolism can compromise the integrity of the intestinal barrier; for example, inactivation of the AMPK pathway may lead to reduced expression of proteins associated with tight junctions. Conversely, impairment of the intestinal barrier can result in metabolic dysregulation, such as alterations in the gut microbiota that impede the production of short-chain fatty acids (SCFAs), which are essential substrates for energy metabolism. This disruption can affect energy production and modify the gut’s hypoxic environment. Imbalances in these systems have been associated with the onset of various intestinal diseases. Research indicates that dietary interventions, such as a low FODMAP diet, can enhance the colonization of probiotics and improve the fermentation metabolism of SCFAs. Pharmacological strategies to elevate SCFA levels can activate the AMPK pathway and rectify abnormalities in energy metabolism. This review provides a comprehensive summary of recent advancements in elucidating the interactions between energy metabolism and the intestinal barrier.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515364/fullenergy metabolismintestinal barrierSCFAscross-talkintestinal diseases |
| spellingShingle | Shuai Chen Caifei Shen Xiaorui Zeng Luqiang Sun Fangli Luo Renhong Wan Yupeng Zhang Xinyun Chen Yujun Hou Wen Wang Qianhua Zheng Ying Li Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases Frontiers in Microbiology energy metabolism intestinal barrier SCFAs cross-talk intestinal diseases |
| title | Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases |
| title_full | Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases |
| title_fullStr | Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases |
| title_full_unstemmed | Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases |
| title_short | Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases |
| title_sort | energy metabolism and the intestinal barrier implications for understanding and managing intestinal diseases |
| topic | energy metabolism intestinal barrier SCFAs cross-talk intestinal diseases |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1515364/full |
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