Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death
Donation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patie...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/680316 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832547548561145856 |
|---|---|
| author | Neehar D. Parikh Anton I. Skaro Daniela P. Ladner Vadim Lyuksemburg Joshua G. Cahan Amna Daud Zeeshan Butt |
| author_facet | Neehar D. Parikh Anton I. Skaro Daniela P. Ladner Vadim Lyuksemburg Joshua G. Cahan Amna Daud Zeeshan Butt |
| author_sort | Neehar D. Parikh |
| collection | DOAJ |
| description | Donation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patients from 2003 to 2010. We compared clinical outcomes of DCD recipients (n=60) to those of donation after brain death (DBD) liver recipients (n=669) during the same time period. DCD recipients had significantly lower rates of 5-year graft survival (P<0.001) and a trend toward lower rates of 5-year patient survival (P=0.064) when compared to the DBD cohort. In order to examine QOL outcomes in our cohorts, we administered the Short Form Liver Disease Quality of Life questionnaire to 30 DCD and 60 DBD recipients. The DCD recipients reported lower generic and liver-specific QOL. We further stratified the DCD cohort by the presence of ischemic cholangiopathy (IC). Patients with IC reported lower QOL when compared to DBD recipients and those DCD recipients without IC (P<0.05). While the results are consistent with clinical experience, this is the first report of QOL in DCD recipients using standardized measures. These data can be used to guide future comparative effectiveness studies. |
| format | Article |
| id | doaj-art-0bfc39e45d224d1aafbe62f5c6222152 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0bfc39e45d224d1aafbe62f5c62221522025-02-03T06:44:13ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/680316680316Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac DeathNeehar D. Parikh0Anton I. Skaro1Daniela P. Ladner2Vadim Lyuksemburg3Joshua G. Cahan4Amna Daud5Zeeshan Butt6Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USANorthwestern University Transplant Outcomes Research Collaborative (NUTORC), Northwestern University, Chicago, IL 60611, USADonation after cardiac death (DCD) has expanded in the last decade in the US; however, DCD liver utilization has flattened in recent years due to poor outcomes. We examined clinical and quality of life (QOL) outcomes of DCD recipients by conducting a retrospective and cross-sectional review of patients from 2003 to 2010. We compared clinical outcomes of DCD recipients (n=60) to those of donation after brain death (DBD) liver recipients (n=669) during the same time period. DCD recipients had significantly lower rates of 5-year graft survival (P<0.001) and a trend toward lower rates of 5-year patient survival (P=0.064) when compared to the DBD cohort. In order to examine QOL outcomes in our cohorts, we administered the Short Form Liver Disease Quality of Life questionnaire to 30 DCD and 60 DBD recipients. The DCD recipients reported lower generic and liver-specific QOL. We further stratified the DCD cohort by the presence of ischemic cholangiopathy (IC). Patients with IC reported lower QOL when compared to DBD recipients and those DCD recipients without IC (P<0.05). While the results are consistent with clinical experience, this is the first report of QOL in DCD recipients using standardized measures. These data can be used to guide future comparative effectiveness studies.http://dx.doi.org/10.1155/2015/680316 |
| spellingShingle | Neehar D. Parikh Anton I. Skaro Daniela P. Ladner Vadim Lyuksemburg Joshua G. Cahan Amna Daud Zeeshan Butt Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death Gastroenterology Research and Practice |
| title | Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death |
| title_full | Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death |
| title_fullStr | Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death |
| title_full_unstemmed | Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death |
| title_short | Clinical Outcomes and Quality of Life in Recipients of Livers Donated after Cardiac Death |
| title_sort | clinical outcomes and quality of life in recipients of livers donated after cardiac death |
| url | http://dx.doi.org/10.1155/2015/680316 |
| work_keys_str_mv | AT neehardparikh clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT antoniskaro clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT danielapladner clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT vadimlyuksemburg clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT joshuagcahan clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT amnadaud clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath AT zeeshanbutt clinicaloutcomesandqualityoflifeinrecipientsofliversdonatedaftercardiacdeath |