ENCODE: A Sourcebook of Epigenomes and Chromatin Language
Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Resear...
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BioMed Central
2013-03-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-11-2.pdf |
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| author | Maryam Yavartanoo Jung Kyoon Choi |
| author_facet | Maryam Yavartanoo Jung Kyoon Choi |
| author_sort | Maryam Yavartanoo |
| collection | DOAJ |
| description | Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Research Institute (NHGRI) launched an international research consortium called Encyclopedia of DNA Elements (ENCODE) to uncover non-coding functional elements in the human genome. The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. The project gives us new insights into the organization and regulation of the human genome and epigenome. Here, we sought to summarize particular aspects of the ENCODE project and highlight the features and data that have recently been released. At the end of this review, we have summarized a case study we conducted using the ENCODE epigenome data. |
| format | Article |
| id | doaj-art-0bf98ab90a23465097fa141698a8bb60 |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-0bf98ab90a23465097fa141698a8bb602025-02-02T23:06:05ZengBioMed CentralGenomics & Informatics1598-866X2234-07422013-03-011112610.5808/GI.2013.11.1.259ENCODE: A Sourcebook of Epigenomes and Chromatin LanguageMaryam Yavartanoo0Jung Kyoon Choi1Department of Bio and Brain Engineering, KAIST, Daejeon 305-701, Korea.Department of Bio and Brain Engineering, KAIST, Daejeon 305-701, Korea.Until recently, since the Human Genome Project, the general view has been that the majority of the human genome is composed of junk DNA and has little or no selective advantage to the organism. Now we know that this conclusion is an oversimplification. In April 2003, the National Human Genome Research Institute (NHGRI) launched an international research consortium called Encyclopedia of DNA Elements (ENCODE) to uncover non-coding functional elements in the human genome. The result of this project has identified a set of new DNA regulatory elements, based on novel relationships among chromatin accessibility, histone modifications, nucleosome positioning, DNA methylation, transcription, and the occupancy of sequence-specific factors. The project gives us new insights into the organization and regulation of the human genome and epigenome. Here, we sought to summarize particular aspects of the ENCODE project and highlight the features and data that have recently been released. At the end of this review, we have summarized a case study we conducted using the ENCODE epigenome data.http://genominfo.org/upload/pdf/gni-11-2.pdfchromatinENCODEhuman genomenucleosome positioningregulatory elements |
| spellingShingle | Maryam Yavartanoo Jung Kyoon Choi ENCODE: A Sourcebook of Epigenomes and Chromatin Language Genomics & Informatics chromatin ENCODE human genome nucleosome positioning regulatory elements |
| title | ENCODE: A Sourcebook of Epigenomes and Chromatin Language |
| title_full | ENCODE: A Sourcebook of Epigenomes and Chromatin Language |
| title_fullStr | ENCODE: A Sourcebook of Epigenomes and Chromatin Language |
| title_full_unstemmed | ENCODE: A Sourcebook of Epigenomes and Chromatin Language |
| title_short | ENCODE: A Sourcebook of Epigenomes and Chromatin Language |
| title_sort | encode a sourcebook of epigenomes and chromatin language |
| topic | chromatin ENCODE human genome nucleosome positioning regulatory elements |
| url | http://genominfo.org/upload/pdf/gni-11-2.pdf |
| work_keys_str_mv | AT maryamyavartanoo encodeasourcebookofepigenomesandchromatinlanguage AT jungkyoonchoi encodeasourcebookofepigenomesandchromatinlanguage |