Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/9798374 |
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| author | Michel Haagdorens Sara Ilse Van Acker Veerle Van Gerwen Sorcha Ní Dhubhghaill Carina Koppen Marie-José Tassignon Nadia Zakaria |
| author_facet | Michel Haagdorens Sara Ilse Van Acker Veerle Van Gerwen Sorcha Ní Dhubhghaill Carina Koppen Marie-José Tassignon Nadia Zakaria |
| author_sort | Michel Haagdorens |
| collection | DOAJ |
| description | Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation. Simple limbal epithelial transplantation reports higher success rates but has not been performed in as many patients yet. This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD. State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction. |
| format | Article |
| id | doaj-art-0be6c5e70dc54a12a0d3be789bdc0f05 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0be6c5e70dc54a12a0d3be789bdc0f052025-02-03T06:01:09ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/97983749798374Limbal Stem Cell Deficiency: Current Treatment Options and Emerging TherapiesMichel Haagdorens0Sara Ilse Van Acker1Veerle Van Gerwen2Sorcha Ní Dhubhghaill3Carina Koppen4Marie-José Tassignon5Nadia Zakaria6Faculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumFaculty of Medicine and Health Sciences, Department of Ophthalmology, Visual Optics and Visual Rehabilitation, University of Antwerp, Campus Drie Eiken, T building, T4-Ophthalmology, Universiteitsplein 1, 2610 Antwerp, BelgiumSevere ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET). Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation. Simple limbal epithelial transplantation reports higher success rates but has not been performed in as many patients yet. This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD. State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction.http://dx.doi.org/10.1155/2016/9798374 |
| spellingShingle | Michel Haagdorens Sara Ilse Van Acker Veerle Van Gerwen Sorcha Ní Dhubhghaill Carina Koppen Marie-José Tassignon Nadia Zakaria Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies Stem Cells International |
| title | Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies |
| title_full | Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies |
| title_fullStr | Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies |
| title_full_unstemmed | Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies |
| title_short | Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies |
| title_sort | limbal stem cell deficiency current treatment options and emerging therapies |
| url | http://dx.doi.org/10.1155/2016/9798374 |
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