Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series
<b>Background/Objectives:</b> The p48 MW HPC is a novel low-profile flow diverter covered by a hydrophilic polymer coating with antithrombogenic properties, which may reduce ischemic complications and enable a single antiplatelet therapy after insertion of the stent. In this single-cente...
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2025-01-01
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| author | Nadja Krug Jan S. Kirschke Christian Maegerlein Kornelia Kreiser Maria Wostrack Bernhard Meyer Carolin Albrecht Claus Zimmer Tobias Boeckh-Behrens Dominik Sepp |
| author_facet | Nadja Krug Jan S. Kirschke Christian Maegerlein Kornelia Kreiser Maria Wostrack Bernhard Meyer Carolin Albrecht Claus Zimmer Tobias Boeckh-Behrens Dominik Sepp |
| author_sort | Nadja Krug |
| collection | DOAJ |
| description | <b>Background/Objectives:</b> The p48 MW HPC is a novel low-profile flow diverter covered by a hydrophilic polymer coating with antithrombogenic properties, which may reduce ischemic complications and enable a single antiplatelet therapy after insertion of the stent. In this single-center experience, we describe the efficacy of this device, focusing on the illustration of different therapeutic indications and the outcome in various clinical settings with regard to vessel anatomy, bleeding state, and aneurysm configuration. <b>Methods:</b> We retrospectively reviewed our database for all patients being treated with a p48 MW HPC flow diverter between February 2019 and July 2021. The efficacy of the treatment was evaluated according to the O’Kelly–Marotta (OKM) scale in the last digital subtraction angiography (DSA) follow-up. Information on complications and medications were collected from our medical records. In addition, to illustrate different indications and clinical settings, we present six of these cases in closer detail. <b>Results:</b> 18 aneurysms in 14 patients were treated with the p48 MW HPC flow diverter and in one case with an additional Derivo device. Periprocedural events occurred in 28.6% of the treated patients, which were all successfully resolved within the same session. Follow-up examination information was available for 67% of patients, of which 75% showed complete occlusion of the aneurysm and 83.3% showed a favorable occlusion result (OKM C-D). Two patients with ruptured aneurysms received a single antiplatelet therapy with ASA without thrombotic complications, at least in the short term. New braid deformation patterns were observed in 16.6% at the follow-up examination, but none with subsequent clinical significance. <b>Conclusions:</b> The p48 MW HPC is safe and effective in the treatment of a wide spectrum of differently configurated, ruptured, and unruptured aneurysms. Single antiplatelet therapy might be an option in selected cases. |
| format | Article |
| id | doaj-art-0bc22f10fd3b4e6ebeff0dd288724244 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj-art-0bc22f10fd3b4e6ebeff0dd2887242442025-01-24T13:25:47ZengMDPI AGBrain Sciences2076-34252025-01-011514210.3390/brainsci15010042Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case SeriesNadja Krug0Jan S. Kirschke1Christian Maegerlein2Kornelia Kreiser3Maria Wostrack4Bernhard Meyer5Carolin Albrecht6Claus Zimmer7Tobias Boeckh-Behrens8Dominik Sepp9Department of Neuroradiology, University Hospital Heidelberg, 69120 Heidelberg, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Radiology and Neuroradiology, University Hospital Ulm, 89081 Ulm, GermanyDepartment of Neurosurgery, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Neurosurgery, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Neurosurgery, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 81675 Munich, GermanyDepartment of Diagnostic and Interventional Neuroradiology, School of Medicine and Health, Technical University of Munich, 81675 Munich, Germany<b>Background/Objectives:</b> The p48 MW HPC is a novel low-profile flow diverter covered by a hydrophilic polymer coating with antithrombogenic properties, which may reduce ischemic complications and enable a single antiplatelet therapy after insertion of the stent. In this single-center experience, we describe the efficacy of this device, focusing on the illustration of different therapeutic indications and the outcome in various clinical settings with regard to vessel anatomy, bleeding state, and aneurysm configuration. <b>Methods:</b> We retrospectively reviewed our database for all patients being treated with a p48 MW HPC flow diverter between February 2019 and July 2021. The efficacy of the treatment was evaluated according to the O’Kelly–Marotta (OKM) scale in the last digital subtraction angiography (DSA) follow-up. Information on complications and medications were collected from our medical records. In addition, to illustrate different indications and clinical settings, we present six of these cases in closer detail. <b>Results:</b> 18 aneurysms in 14 patients were treated with the p48 MW HPC flow diverter and in one case with an additional Derivo device. Periprocedural events occurred in 28.6% of the treated patients, which were all successfully resolved within the same session. Follow-up examination information was available for 67% of patients, of which 75% showed complete occlusion of the aneurysm and 83.3% showed a favorable occlusion result (OKM C-D). Two patients with ruptured aneurysms received a single antiplatelet therapy with ASA without thrombotic complications, at least in the short term. New braid deformation patterns were observed in 16.6% at the follow-up examination, but none with subsequent clinical significance. <b>Conclusions:</b> The p48 MW HPC is safe and effective in the treatment of a wide spectrum of differently configurated, ruptured, and unruptured aneurysms. Single antiplatelet therapy might be an option in selected cases.https://www.mdpi.com/2076-3425/15/1/42flow diversionintracranial aneurysmsp48 MW HPCendovascular treatment |
| spellingShingle | Nadja Krug Jan S. Kirschke Christian Maegerlein Kornelia Kreiser Maria Wostrack Bernhard Meyer Carolin Albrecht Claus Zimmer Tobias Boeckh-Behrens Dominik Sepp Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series Brain Sciences flow diversion intracranial aneurysms p48 MW HPC endovascular treatment |
| title | Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series |
| title_full | Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series |
| title_fullStr | Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series |
| title_full_unstemmed | Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series |
| title_short | Intracranial Aneurysms Treated with a Novel Coated Low-Profile Flow Diverter (p48 HPC)—A Single-Center Experience and an Illustrative Case Series |
| title_sort | intracranial aneurysms treated with a novel coated low profile flow diverter p48 hpc a single center experience and an illustrative case series |
| topic | flow diversion intracranial aneurysms p48 MW HPC endovascular treatment |
| url | https://www.mdpi.com/2076-3425/15/1/42 |
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