Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes
Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-s...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/320930 |
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| author | M. R. Lopes Paula A. B. Ribeiro Priscila Ledur Gabriela C. Souza Nadine Clausell Beatriz D. Schaan |
| author_facet | M. R. Lopes Paula A. B. Ribeiro Priscila Ledur Gabriela C. Souza Nadine Clausell Beatriz D. Schaan |
| author_sort | M. R. Lopes |
| collection | DOAJ |
| description | Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C, n=25), vitamin sufficient, diabetes (DS-DM, n=18), vitamin deficient, no diabetes (DD-C, n= 63), and vitamin deficient, diabetes (DD-DM, n=40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups (P=0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m) versus DD-DM (309 ± 116 m); P=0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM (P=0.074) even after being adjusted to physical activity (P=0.069). Vitamin D deficiency can influence physical function in HF diabetic patients. |
| format | Article |
| id | doaj-art-0bc0d5554c0844c1835c8477d112ae6e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-0bc0d5554c0844c1835c8477d112ae6e2025-02-03T01:03:01ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/320930320930Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and DiabetesM. R. Lopes0Paula A. B. Ribeiro1Priscila Ledur2Gabriela C. Souza3Nadine Clausell4Beatriz D. Schaan5Endocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilCardiology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilEndocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilDepartment of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilCardiology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilEndocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, BrazilVitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C, n=25), vitamin sufficient, diabetes (DS-DM, n=18), vitamin deficient, no diabetes (DD-C, n= 63), and vitamin deficient, diabetes (DD-DM, n=40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups (P=0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m) versus DD-DM (309 ± 116 m); P=0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM (P=0.074) even after being adjusted to physical activity (P=0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.http://dx.doi.org/10.1155/2014/320930 |
| spellingShingle | M. R. Lopes Paula A. B. Ribeiro Priscila Ledur Gabriela C. Souza Nadine Clausell Beatriz D. Schaan Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes Journal of Diabetes Research |
| title | Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes |
| title_full | Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes |
| title_fullStr | Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes |
| title_full_unstemmed | Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes |
| title_short | Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes |
| title_sort | vitamin d insufficiency is associated with lower physical function in patients with heart failure and diabetes |
| url | http://dx.doi.org/10.1155/2014/320930 |
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