Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism
Zinc supplementation is recommended in all acute diarrheas in children from developing countries. We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas. We used data on 801 children with acute diarrhea recruited in...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2010/671587 |
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| author | Archana B. Patel Michael J. Dibley Manju Mamtani Neetu Badhoniya Hemant Kulkarni |
| author_facet | Archana B. Patel Michael J. Dibley Manju Mamtani Neetu Badhoniya Hemant Kulkarni |
| author_sort | Archana B. Patel |
| collection | DOAJ |
| description | Zinc supplementation is recommended in all acute diarrheas in children from developing countries. We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas. We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation. Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. Although we found similar results for the outcome of high stool volume, the results did not reach statistical significance. Our findings suggest that the current strategy of zinc supplementation in all cases of acute diarrheas in children may need appropriate fine tuning to optimize the therapeutic benefit based on the causative organism, but further studies need to confirm and extend our findings. |
| format | Article |
| id | doaj-art-0bbecbbe72d5436db529b190490d4c67 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-0bbecbbe72d5436db529b190490d4c672025-02-03T01:27:38ZengWileyInternational Journal of Pediatrics1687-97401687-97592010-01-01201010.1155/2010/671587671587Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated OrganismArchana B. Patel0Michael J. Dibley1Manju Mamtani2Neetu Badhoniya3Hemant Kulkarni4NGO, Lata Medical Research Foundation, Nagpur 440022, IndiaThe Sydney School of Public Health, University of Sydney, 2006 Sydney, AustraliaNGO, Lata Medical Research Foundation, Nagpur 440022, IndiaNGO, Lata Medical Research Foundation, Nagpur 440022, IndiaNGO, Lata Medical Research Foundation, Nagpur 440022, IndiaZinc supplementation is recommended in all acute diarrheas in children from developing countries. We aimed to assess whether zinc supplementation would be equally effective against all the common organisms associated with acute diarrheas. We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation. Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. Although we found similar results for the outcome of high stool volume, the results did not reach statistical significance. Our findings suggest that the current strategy of zinc supplementation in all cases of acute diarrheas in children may need appropriate fine tuning to optimize the therapeutic benefit based on the causative organism, but further studies need to confirm and extend our findings.http://dx.doi.org/10.1155/2010/671587 |
| spellingShingle | Archana B. Patel Michael J. Dibley Manju Mamtani Neetu Badhoniya Hemant Kulkarni Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism International Journal of Pediatrics |
| title | Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism |
| title_full | Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism |
| title_fullStr | Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism |
| title_full_unstemmed | Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism |
| title_short | Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism |
| title_sort | influence of zinc supplementation in acute diarrhea differs by the isolated organism |
| url | http://dx.doi.org/10.1155/2010/671587 |
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