Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC)
In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000591 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555841145798656 |
|---|---|
| author | M. Jäpel H. Lötzerich K. Rogalla |
| author_facet | M. Jäpel H. Lötzerich K. Rogalla |
| author_sort | M. Jäpel |
| collection | DOAJ |
| description | In addition to the spectrum of biological action already known to be
exhibited by acetylsalicylic acid (ASA) as an analgesic,
anti-inflammatory and platelet aggregation inhibitor, there is
growing evidence of a stimulatory effect on the immune system. ASA
has been found to increase the production ofcytokines and to
increase the activity of various leukocytes. The action of ASA on
the activity of mouse peritoneal macrophages was therefore
investigated in the present study. Therapeutically effective
concentrations of ASA, which are known to decrease levels of
prostaglandins, had neither a stimulating nor an inhibiting
influence on antibody-dependent cellular cytotoxicity (ADCC) or on
the binding capacity of macrophages with regard to SW 948 tumour
cells. Likewise ASA had little or no adverse effect on the capacity
of the macrophages for stimulation by interferon-gamma (IFN-gamma)
and interleukin-4 (IL-4). Taken together, the immunostimulant effect
of ASA shown in the literature as an increased production of
interleukin-2 (IL-2) and IFN, could not be confirmed on the basis of
the macrophage cytotoxiclty. |
| format | Article |
| id | doaj-art-0bbb948400614e00988bdb59b21b51bd |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0bbb948400614e00988bdb59b21b51bd2025-02-03T05:46:59ZengWileyMediators of Inflammation0962-93511466-18611994-01-013641942410.1155/S0962935194000591Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC)M. Jäpel0H. Lötzerich1K. Rogalla2Institute for Experimental Morphology, German Sports University, P.O. Box 45 03 27, Köln 50927, GermanyInstitute for Experimental Morphology, German Sports University, P.O. Box 45 03 27, Köln 50927, GermanyDrug Research Center, Bayer AG, Aprather Weg, Wuppertal 1 5600, GermanyIn addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to increase the activity of various leukocytes. The action of ASA on the activity of mouse peritoneal macrophages was therefore investigated in the present study. Therapeutically effective concentrations of ASA, which are known to decrease levels of prostaglandins, had neither a stimulating nor an inhibiting influence on antibody-dependent cellular cytotoxicity (ADCC) or on the binding capacity of macrophages with regard to SW 948 tumour cells. Likewise ASA had little or no adverse effect on the capacity of the macrophages for stimulation by interferon-gamma (IFN-gamma) and interleukin-4 (IL-4). Taken together, the immunostimulant effect of ASA shown in the literature as an increased production of interleukin-2 (IL-2) and IFN, could not be confirmed on the basis of the macrophage cytotoxiclty.http://dx.doi.org/10.1155/S0962935194000591 |
| spellingShingle | M. Jäpel H. Lötzerich K. Rogalla Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages in Antibody-Dependent Cellular Cytotoxicity (ADCC) Mediators of Inflammation |
| title | Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages
in Antibody-Dependent Cellular Cytotoxicity (ADCC) |
| title_full | Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages
in Antibody-Dependent Cellular Cytotoxicity (ADCC) |
| title_fullStr | Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages
in Antibody-Dependent Cellular Cytotoxicity (ADCC) |
| title_full_unstemmed | Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages
in Antibody-Dependent Cellular Cytotoxicity (ADCC) |
| title_short | Role of Acetylsalicylic Acid in Cytokine Stimulation of Macrophages
in Antibody-Dependent Cellular Cytotoxicity (ADCC) |
| title_sort | role of acetylsalicylic acid in cytokine stimulation of macrophages in antibody dependent cellular cytotoxicity adcc |
| url | http://dx.doi.org/10.1155/S0962935194000591 |
| work_keys_str_mv | AT mjapel roleofacetylsalicylicacidincytokinestimulationofmacrophagesinantibodydependentcellularcytotoxicityadcc AT hlotzerich roleofacetylsalicylicacidincytokinestimulationofmacrophagesinantibodydependentcellularcytotoxicityadcc AT krogalla roleofacetylsalicylicacidincytokinestimulationofmacrophagesinantibodydependentcellularcytotoxicityadcc |