Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters
ObjectiveTo explore the value of the ratio of fetal cerebellar transverse diameter to abdominal circumference (TCD/AC) combined with uterine artery blood flow parameters in the assessment of fetal growth restriction (FGR).MethodsA retrospective analysis was conducted, including 152 women diagnosed w...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1633122/full |
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| author | Weiying Tang Pingping Wu Yanyan Zheng Baobao Yang |
| author_facet | Weiying Tang Pingping Wu Yanyan Zheng Baobao Yang |
| author_sort | Weiying Tang |
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| description | ObjectiveTo explore the value of the ratio of fetal cerebellar transverse diameter to abdominal circumference (TCD/AC) combined with uterine artery blood flow parameters in the assessment of fetal growth restriction (FGR).MethodsA retrospective analysis was conducted, including 152 women diagnosed with FGR through prenatal ultrasound screening at our hospital between January 2020 and December 2024 as the FGR group, and 156 pregnant women with normal prenatal examinations during the same period were included as the non-FGR group using a stratified sampling method. Parameters such as TCD/AC, head circumference to abdominal circumference ratio (HC/AC), and hemodynamic indicators of uterine and cerebral artery blood flow were measured through ultrasound examinations. Blood biomarkers such as insulin-like growth factor 1 (IGF-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were also assessed.ResultsThere were no statistically significant differences between the two groups in terms of age, BMI, gestational weeks, parity, and gravidity (P > 0.05). The TCD/AC and HC/AC ratios in the FGR group were significantly lower than those in the non-FGR group (P < 0.05), while the uterine artery pulsatility index (PI), resistance index (RI), and systolic to diastolic peak velocity ratio (S/D) were significantly higher in the FGR group (P < 0.05). Additionally, levels of IGF-1, PlGF, and VEGF were significantly lower in the FGR group (P < 0.05). Multivariable logistic regression analysis revealed that TCD/AC, uterine artery PI (UtA-PI), uterine artery RI (UtA-RI), and uterine artery S/D (UtA-S/D) were independent predictors of FGR. Receiver operating characteristic (ROC) curve analysis demonstrated that when these indicators were used in combination, the diagnostic efficiency of FGR was improved, with an AUC of 0.820.ConclusionThe combination of TCD/AC with uterine artery blood flow parameters has high predictive value for FGR and can serve as an effective tool for early identification and management of FGR in clinical practice. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-0bba9b2a1e8e4e249ffff5f2b7e6aeb42025-08-20T03:25:27ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-07-011310.3389/fped.2025.16331221633122Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parametersWeiying Tang0Pingping Wu1Yanyan Zheng2Baobao Yang3Department of Obstetrics, Cangnan People ’s Hospital, Wenzhou, Zhejiang, ChinaDepartment of Ultrasound, Cangnan People ’s Hospital, Wenzhou, Zhejiang, ChinaDepartment of Obstetrics, Cangnan People ’s Hospital, Wenzhou, Zhejiang, ChinaDepartment of Obstetrics, Cangnan People ’s Hospital, Wenzhou, Zhejiang, ChinaObjectiveTo explore the value of the ratio of fetal cerebellar transverse diameter to abdominal circumference (TCD/AC) combined with uterine artery blood flow parameters in the assessment of fetal growth restriction (FGR).MethodsA retrospective analysis was conducted, including 152 women diagnosed with FGR through prenatal ultrasound screening at our hospital between January 2020 and December 2024 as the FGR group, and 156 pregnant women with normal prenatal examinations during the same period were included as the non-FGR group using a stratified sampling method. Parameters such as TCD/AC, head circumference to abdominal circumference ratio (HC/AC), and hemodynamic indicators of uterine and cerebral artery blood flow were measured through ultrasound examinations. Blood biomarkers such as insulin-like growth factor 1 (IGF-1), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were also assessed.ResultsThere were no statistically significant differences between the two groups in terms of age, BMI, gestational weeks, parity, and gravidity (P > 0.05). The TCD/AC and HC/AC ratios in the FGR group were significantly lower than those in the non-FGR group (P < 0.05), while the uterine artery pulsatility index (PI), resistance index (RI), and systolic to diastolic peak velocity ratio (S/D) were significantly higher in the FGR group (P < 0.05). Additionally, levels of IGF-1, PlGF, and VEGF were significantly lower in the FGR group (P < 0.05). Multivariable logistic regression analysis revealed that TCD/AC, uterine artery PI (UtA-PI), uterine artery RI (UtA-RI), and uterine artery S/D (UtA-S/D) were independent predictors of FGR. Receiver operating characteristic (ROC) curve analysis demonstrated that when these indicators were used in combination, the diagnostic efficiency of FGR was improved, with an AUC of 0.820.ConclusionThe combination of TCD/AC with uterine artery blood flow parameters has high predictive value for FGR and can serve as an effective tool for early identification and management of FGR in clinical practice.https://www.frontiersin.org/articles/10.3389/fped.2025.1633122/fullfetal growth restrictionratio of fetal cerebellar transverse diameter to abdominal circumferenceuterine artery blood flow parametersprediction valueultrasound examinationblood biomarkers |
| spellingShingle | Weiying Tang Pingping Wu Yanyan Zheng Baobao Yang Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters Frontiers in Pediatrics fetal growth restriction ratio of fetal cerebellar transverse diameter to abdominal circumference uterine artery blood flow parameters prediction value ultrasound examination blood biomarkers |
| title | Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| title_full | Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| title_fullStr | Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| title_full_unstemmed | Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| title_short | Comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| title_sort | comprehensive evaluation of the prediction of fetal growth restriction using the ratio of fetal cerebellar transverse diameter to abdominal circumference combined with uterine artery blood flow parameters |
| topic | fetal growth restriction ratio of fetal cerebellar transverse diameter to abdominal circumference uterine artery blood flow parameters prediction value ultrasound examination blood biomarkers |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1633122/full |
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