A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever
Fever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug’s effects, various inflammatory disorders, and cancers. Among the latter, lymphomas can indeed cause fever, which is therefore accounted as a lymphoma-related sign in...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1480710 |
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| author | Pier Paolo Piccaluga Stefania Paolini Cristina Campidelli Nicola Vianelli Luigi Bolondi |
| author_facet | Pier Paolo Piccaluga Stefania Paolini Cristina Campidelli Nicola Vianelli Luigi Bolondi |
| author_sort | Pier Paolo Piccaluga |
| collection | DOAJ |
| description | Fever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug’s effects, various inflammatory disorders, and cancers. Among the latter, lymphomas can indeed cause fever, which is therefore accounted as a lymphoma-related sign in patients’ staging. Intravascular large B-cell lymphoma (IVLBCL) is a very rare tumor, characterized by lymphoma cell accumulation within sinusoids and, despite a very aggressive course, the evidence of this disease is scarce. Two variants are currently recognized, respectively, occurring in either Western (mainly characterized by neurological symptoms and skin involvement) or Eastern countries (with hemophagocytic syndrome, bone marrow, spleen, and liver involvement). We describe an atypical and unprecedented IVLBCL patient, presenting with pronounced features of Eastern cases as well as skin involvement. Due to the scant amount of neoplastic cells, the diagnosis was very challenging, with FUO being the first and for a certain time unique clinical sign. Although lymphoma was suspected, the lack of evidence for neoplastic cells delayed the final diagnosis. Eventually, only autopsy revealed the extensive involvement of different organs and tissues. |
| format | Article |
| id | doaj-art-0bb6ce9338764f83ae6927bab4689ea3 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0bb6ce9338764f83ae6927bab4689ea32025-02-03T01:21:33ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/14807101480710A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent FeverPier Paolo Piccaluga0Stefania Paolini1Cristina Campidelli2Nicola Vianelli3Luigi Bolondi4Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Bologna, ItalyS. Orsola-Malpighi Hospital, Hematology and Hematopathology Units, Bologna, ItalyAzienda Ospedaliera Ospedali di Legnano, U. O. Anatomia Patologica, Legnao, Milan, ItalyS. Orsola-Malpighi Hospital, Hematology and Hematopathology Units, Bologna, ItalyDepartment of Medical and Surgical Sciences, University of Bologna, Bologna, ItalyFever of unknown origin (FUO) is a common and challenging clinical condition that can be referred, among others, to infections, drug’s effects, various inflammatory disorders, and cancers. Among the latter, lymphomas can indeed cause fever, which is therefore accounted as a lymphoma-related sign in patients’ staging. Intravascular large B-cell lymphoma (IVLBCL) is a very rare tumor, characterized by lymphoma cell accumulation within sinusoids and, despite a very aggressive course, the evidence of this disease is scarce. Two variants are currently recognized, respectively, occurring in either Western (mainly characterized by neurological symptoms and skin involvement) or Eastern countries (with hemophagocytic syndrome, bone marrow, spleen, and liver involvement). We describe an atypical and unprecedented IVLBCL patient, presenting with pronounced features of Eastern cases as well as skin involvement. Due to the scant amount of neoplastic cells, the diagnosis was very challenging, with FUO being the first and for a certain time unique clinical sign. Although lymphoma was suspected, the lack of evidence for neoplastic cells delayed the final diagnosis. Eventually, only autopsy revealed the extensive involvement of different organs and tissues.http://dx.doi.org/10.1155/2019/1480710 |
| spellingShingle | Pier Paolo Piccaluga Stefania Paolini Cristina Campidelli Nicola Vianelli Luigi Bolondi A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever Case Reports in Hematology |
| title | A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever |
| title_full | A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever |
| title_fullStr | A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever |
| title_full_unstemmed | A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever |
| title_short | A Western Case of Intravascular Large B-Cell Lymphoma as Unusual Cause of Persistent Fever |
| title_sort | western case of intravascular large b cell lymphoma as unusual cause of persistent fever |
| url | http://dx.doi.org/10.1155/2019/1480710 |
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