Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study
Longitudinal melanonychia can be caused by melanocyte activation (hypermelanosis) or proliferation (lentigo, nevus or melanoma). Histopathologic examination is mandatory for suspicious cases of melanomas. Tangential biopsy of the matrix is an elegant technique avoiding nail plate dystrophy, but it...
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Wiley
2012-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/353864 |
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| author | Nilton Di Chiacchio Walter Refkalefsky Loureiro Nilceo Schwery Michalany Felipe Veiga Kezam Gabriel |
| author_facet | Nilton Di Chiacchio Walter Refkalefsky Loureiro Nilceo Schwery Michalany Felipe Veiga Kezam Gabriel |
| author_sort | Nilton Di Chiacchio |
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| description | Longitudinal melanonychia can be caused by melanocyte activation (hypermelanosis) or proliferation (lentigo, nevus or melanoma). Histopathologic examination is mandatory for suspicious cases of melanomas. Tangential biopsy of the matrix is an elegant technique avoiding nail plate dystrophy, but it was unknown whether the depth of the sample obtained by this method is adequate for histopathologic diagnosis. Twenty-two patients with longitudinal melanonychia striata were submitted to tangential matrix biopsies described by Haneke. The tissue was stained with hematoxylin-eosin and the specimens were measured at 3 distinct points according to the total thickness: largest (A), intermediate (B) and narrowest (C) then divided into 4 groups according to the histopathologic diagnosis (G1: hypermelanosis; G2: lentigos; G3: nevus; G4: melanoma). The lesions were measured using the same method. The mean specimen/lesion thickness measure values for each group was: G1: 0,59/0,10 mm, G2: 0,67/0,08 mm, G3: 0,52/0,05 mm, G4: 0,58/0,10 mm. The general average thickness for all the specimens/lesions was 0,59/0,08 mm. We concluded that the tangential excision, for longitudinal melanonychia, provides an adequate material for histopathological diagnosis. |
| format | Article |
| id | doaj-art-0bb0f92869a44267b352206f3c82a13e |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| spelling | doaj-art-0bb0f92869a44267b352206f3c82a13e2025-02-03T01:22:24ZengWileyDermatology Research and Practice1687-61051687-61132012-01-01201210.1155/2012/353864353864Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot StudyNilton Di Chiacchio0Walter Refkalefsky Loureiro1Nilceo Schwery Michalany2Felipe Veiga Kezam Gabriel3Dermatologic Clinic, Hospital do Servidor Público Municipal de São Paulo, Rua Castro Alves 131, 01532-001 São Paulo, SP, BrazilDermatologic Clinic, Hospital do Servidor Público Municipal de São Paulo, Rua Castro Alves 131, 01532-001 São Paulo, SP, BrazilLaboratório Paulista de Dermatologia Avenida Brigadeiro Luís Antônio 4315, Universidade Federal de São Paulo, 01401-002 São Paulo, SP, BrazilDermatologic Clinic, Hospital do Servidor Público Municipal de São Paulo, Rua Castro Alves 131, 01532-001 São Paulo, SP, BrazilLongitudinal melanonychia can be caused by melanocyte activation (hypermelanosis) or proliferation (lentigo, nevus or melanoma). Histopathologic examination is mandatory for suspicious cases of melanomas. Tangential biopsy of the matrix is an elegant technique avoiding nail plate dystrophy, but it was unknown whether the depth of the sample obtained by this method is adequate for histopathologic diagnosis. Twenty-two patients with longitudinal melanonychia striata were submitted to tangential matrix biopsies described by Haneke. The tissue was stained with hematoxylin-eosin and the specimens were measured at 3 distinct points according to the total thickness: largest (A), intermediate (B) and narrowest (C) then divided into 4 groups according to the histopathologic diagnosis (G1: hypermelanosis; G2: lentigos; G3: nevus; G4: melanoma). The lesions were measured using the same method. The mean specimen/lesion thickness measure values for each group was: G1: 0,59/0,10 mm, G2: 0,67/0,08 mm, G3: 0,52/0,05 mm, G4: 0,58/0,10 mm. The general average thickness for all the specimens/lesions was 0,59/0,08 mm. We concluded that the tangential excision, for longitudinal melanonychia, provides an adequate material for histopathological diagnosis.http://dx.doi.org/10.1155/2012/353864 |
| spellingShingle | Nilton Di Chiacchio Walter Refkalefsky Loureiro Nilceo Schwery Michalany Felipe Veiga Kezam Gabriel Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study Dermatology Research and Practice |
| title | Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study |
| title_full | Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study |
| title_fullStr | Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study |
| title_full_unstemmed | Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study |
| title_short | Tangential Biopsy Thickness versus Lesion Depth in Longitudinal Melanonychia: A Pilot Study |
| title_sort | tangential biopsy thickness versus lesion depth in longitudinal melanonychia a pilot study |
| url | http://dx.doi.org/10.1155/2012/353864 |
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