A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6
We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene). During hospitalization, prolonged QTc intervals and frequent episodes of ventricular tachyarrhythmias ma...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/1384139 |
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| _version_ | 1832560921597181952 |
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| author | Annejet Heida Lisette J. M. E. van der Does Ahmed A. Y. Ragab Natasja M. S. de Groot |
| author_facet | Annejet Heida Lisette J. M. E. van der Does Ahmed A. Y. Ragab Natasja M. S. de Groot |
| author_sort | Annejet Heida |
| collection | DOAJ |
| description | We report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene). During hospitalization, prolonged QTc intervals and frequent episodes of ventricular tachyarrhythmias manifested. Genetic testing identified a mutation of the KCNH2 gene and an unclassified variant, most likely pathogenic, of the KCNE2 gene. This digenic inheritance is extremely rare. |
| format | Article |
| id | doaj-art-0babb93bce2c4af3907eb43c9ef518e3 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-0babb93bce2c4af3907eb43c9ef518e32025-02-03T01:26:17ZengWileyCase Reports in Medicine1687-96271687-96352019-01-01201910.1155/2019/13841391384139A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6Annejet Heida0Lisette J. M. E. van der Does1Ahmed A. Y. Ragab2Natasja M. S. de Groot3Department of Cardiology, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, NetherlandsDepartment of Cardiology, Erasmus Medical Center, Rotterdam, NetherlandsWe report a 37-year-old woman with an out-of-hospital cardiac arrest caused by ventricular fibrillation due to digenic inheritance of long QT syndrome type 2 (KCNH2 gene) and type 6 (KCNE2 gene). During hospitalization, prolonged QTc intervals and frequent episodes of ventricular tachyarrhythmias manifested. Genetic testing identified a mutation of the KCNH2 gene and an unclassified variant, most likely pathogenic, of the KCNE2 gene. This digenic inheritance is extremely rare.http://dx.doi.org/10.1155/2019/1384139 |
| spellingShingle | Annejet Heida Lisette J. M. E. van der Does Ahmed A. Y. Ragab Natasja M. S. de Groot A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 Case Reports in Medicine |
| title | A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 |
| title_full | A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 |
| title_fullStr | A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 |
| title_full_unstemmed | A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 |
| title_short | A Rare Case of the Digenic Inheritance of Long QT Syndrome Type 2 and Type 6 |
| title_sort | rare case of the digenic inheritance of long qt syndrome type 2 and type 6 |
| url | http://dx.doi.org/10.1155/2019/1384139 |
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