HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib

HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib

Abstract Background Hepatocellular carcinoma (HCC) has a poor prognosis, partly due to resistance to treatments like sorafenib. The 5-hydroxytryptamine receptor 1D (HTR1D) is involved in cancer progression through the PI3K/Akt pathway, but its role in HCC is not well understood. This study investiga...

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Bibliographic Details
Main Authors: Yingai Zhang, Yuting Zhang, Shuai Zhou, Mujeeb Ur Rehman, Fankai Lin, Jianquan Zhang, Hailong Zhou
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Hepatocellular carcinoma
HTR1D
Sorafenib resistance
PI3K/Akt
Online Access:https://doi.org/10.1186/s12885-025-13575-5
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