Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration
<b>Background:</b> The impact of Celiac Disease (CD) is not only limited to the intestinal system, but extraintestinal manifestations may also be seen. In this context, cardiac manifestations have recently been the focus of attention. This study aimed to evaluate myocardial repolarizatio...
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2025-01-01
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| author | Betül Ayça Yamak İbrahim Ethem Güven Mustafa Candemir |
| author_facet | Betül Ayça Yamak İbrahim Ethem Güven Mustafa Candemir |
| author_sort | Betül Ayça Yamak |
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| description | <b>Background:</b> The impact of Celiac Disease (CD) is not only limited to the intestinal system, but extraintestinal manifestations may also be seen. In this context, cardiac manifestations have recently been the focus of attention. This study aimed to evaluate myocardial repolarization properties in CD patients by assessing the frontal QRS-T Angle (fQRS-T) on electrocardiography (ECG). <b>Methods:</b> A total of 302 patients, including 150 CD patients and 152 control group patients, were included in the study. ECG parameters, including fQRS-T, QRS interval, and QTc interval, were calculated for each patient and compared between the groups. In addition, the relationship of these ECG parameters with disease duration was also analyzed. <b>Results:</b> The median disease duration was 38.5 (16 to 96) months in the CD group. Significantly wider QRS interval (92 (86 to 96) vs. 83 (76.3 to 93), <i>p</i> < 0.001) and fQRS-T (23 (13 to 37) vs. 18 (6.3 to 27), <i>p</i> < 0.001) values were observed in the CD group. Among CD patients, those with longer disease duration (>38.5 months) exhibited significantly wider QRS intervals (94 (88 to 98) vs. 88 (84 to 94), <i>p</i> < 0.001) and frontal QRS-T angles (29 (14 to 47) vs. 16 (10 to 25), <i>p</i> < 0.001) compared to those with shorter disease duration. A positive correlation between the disease duration and fQRS-T was also demonstrated (r = 0.478, <i>p</i> < 0.001). Multivariable logistic regression identified QRS interval (OR: 1.060, 95% CI: 1.032–1.088, <i>p</i> < 0.001) and frontal QRS-T angle (OR: 1.028, 95% CI: 1.013–1.043, <i>p</i> < 0.001) as independent predictors of CD. Additionally, the QRS interval (OR: 1.066, 95% CI: 1.012–1.124, <i>p</i> = 0.016) and frontal QRS-T angle (OR: 1.021, 95% CI: 1.003–1.038, <i>p</i> = 0.021) were significant predictors of longer disease duration. A linear regression analysis confirmed that disease duration was a stronger predictor of frontal QRS-T angle widening (B: 0.389, 95% CI: 0.102–0.677, <i>p</i> < 0.001) compared to age (B: 0.184, 95% CI: 0.123–0.245, <i>p</i> = 0.008). <b>Conclusions:</b> In this study, we demonstrated that chronic inflammation secondary to CD may have negative effects on cardiac repolarization and that this effect is closely related to disease duration. |
| format | Article |
| id | doaj-art-0b8caa55162241e58dc0c61c053f6916 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-0b8caa55162241e58dc0c61c053f69162025-01-24T13:29:02ZengMDPI AGDiagnostics2075-44182025-01-0115218710.3390/diagnostics15020187Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease DurationBetül Ayça Yamak0İbrahim Ethem Güven1Mustafa Candemir2Department of Cardiology, Hopa State Hospital, 08600 Artvin, TurkeyDepartment of Gastroenterology, Yenimahalle Education and Research Hospital, 06370 Ankara, TurkeyDepartment of Cardiology, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey<b>Background:</b> The impact of Celiac Disease (CD) is not only limited to the intestinal system, but extraintestinal manifestations may also be seen. In this context, cardiac manifestations have recently been the focus of attention. This study aimed to evaluate myocardial repolarization properties in CD patients by assessing the frontal QRS-T Angle (fQRS-T) on electrocardiography (ECG). <b>Methods:</b> A total of 302 patients, including 150 CD patients and 152 control group patients, were included in the study. ECG parameters, including fQRS-T, QRS interval, and QTc interval, were calculated for each patient and compared between the groups. In addition, the relationship of these ECG parameters with disease duration was also analyzed. <b>Results:</b> The median disease duration was 38.5 (16 to 96) months in the CD group. Significantly wider QRS interval (92 (86 to 96) vs. 83 (76.3 to 93), <i>p</i> < 0.001) and fQRS-T (23 (13 to 37) vs. 18 (6.3 to 27), <i>p</i> < 0.001) values were observed in the CD group. Among CD patients, those with longer disease duration (>38.5 months) exhibited significantly wider QRS intervals (94 (88 to 98) vs. 88 (84 to 94), <i>p</i> < 0.001) and frontal QRS-T angles (29 (14 to 47) vs. 16 (10 to 25), <i>p</i> < 0.001) compared to those with shorter disease duration. A positive correlation between the disease duration and fQRS-T was also demonstrated (r = 0.478, <i>p</i> < 0.001). Multivariable logistic regression identified QRS interval (OR: 1.060, 95% CI: 1.032–1.088, <i>p</i> < 0.001) and frontal QRS-T angle (OR: 1.028, 95% CI: 1.013–1.043, <i>p</i> < 0.001) as independent predictors of CD. Additionally, the QRS interval (OR: 1.066, 95% CI: 1.012–1.124, <i>p</i> = 0.016) and frontal QRS-T angle (OR: 1.021, 95% CI: 1.003–1.038, <i>p</i> = 0.021) were significant predictors of longer disease duration. A linear regression analysis confirmed that disease duration was a stronger predictor of frontal QRS-T angle widening (B: 0.389, 95% CI: 0.102–0.677, <i>p</i> < 0.001) compared to age (B: 0.184, 95% CI: 0.123–0.245, <i>p</i> = 0.008). <b>Conclusions:</b> In this study, we demonstrated that chronic inflammation secondary to CD may have negative effects on cardiac repolarization and that this effect is closely related to disease duration.https://www.mdpi.com/2075-4418/15/2/187celiac diseaseelectrocardiographyfrontal QRS-T angle |
| spellingShingle | Betül Ayça Yamak İbrahim Ethem Güven Mustafa Candemir Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration Diagnostics celiac disease electrocardiography frontal QRS-T angle |
| title | Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration |
| title_full | Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration |
| title_fullStr | Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration |
| title_full_unstemmed | Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration |
| title_short | Electrocardiographic Frontal QRS-T Angle Is Independently Associated with the Presence of Celiac Disease and Disease Duration |
| title_sort | electrocardiographic frontal qrs t angle is independently associated with the presence of celiac disease and disease duration |
| topic | celiac disease electrocardiography frontal QRS-T angle |
| url | https://www.mdpi.com/2075-4418/15/2/187 |
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