Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes

Genotype-specific differences in infertile men due to loss-of-function variants in M1AP or ZZS genes

Abstract Male infertility has been linked to M1AP. In mice, M1AP interacts with the ZZS proteins SHOC1/TEX11/SPO16, promoting DNA class I crossover formation during meiosis. To determine whether M1AP and ZZS proteins are involved in human male infertility by recombination failure, we screened for bi...

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Main Authors: Nadja Rotte, Jessica E M Dunleavy, Michelle D Runkel, Lina Bosse, Daniela Fietz, Adrian Pilatz, Johanna Kuss, Ann-Kristin Dicke, Sofia B Winge, Sara Di Persio, Christian Ruckert, Verena Nordhoff, Hans-Christian Schuppe, Kristian Almstrup, Sabine Kliesch, Nina Neuhaus, Birgit Stallmeyer, Moira K O’Bryan, Frank Tüttelmann, Corinna Friedrich
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:EMBO Molecular Medicine
Subjects:
M1AP
Meiosis
Crossover
Infertility
Recombination
Online Access:https://doi.org/10.1038/s44321-025-00244-0
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https://doi.org/10.1038/s44321-025-00244-0

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