Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid
39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS)...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/854795 |
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| author | Aikaterini Patsatsi Aikaterini Kyriakou Aikaterini Pavlitou-Tsiontsi Anastasia Giannakou Dimitrios Sotiriadis |
| author_facet | Aikaterini Patsatsi Aikaterini Kyriakou Aikaterini Pavlitou-Tsiontsi Anastasia Giannakou Dimitrios Sotiriadis |
| author_sort | Aikaterini Patsatsi |
| collection | DOAJ |
| description | 39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All parameters were evaluated by the time of diagnosis (baseline), month 3, and month 6. Titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with BPDAI component for the intensity of pruritus (, ) at baseline. At month 3, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with the BPDAI component for the intensity of pruritus (, ). At month 6, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with the BPDAI component for the intensity of pruritus (, ). There was no statistically significant correlation between titers of anti-BP230 autoantibodies and the BPDAI, ABSIS, and BPDAI component for the intensity of pruritus at the same time points. |
| format | Article |
| id | doaj-art-0b8934f57bbf4494a291168c7fde8aa2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-0b8934f57bbf4494a291168c7fde8aa22025-02-03T05:48:17ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/854795854795Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous PemphigoidAikaterini Patsatsi0Aikaterini Kyriakou1Aikaterini Pavlitou-Tsiontsi2Anastasia Giannakou3Dimitrios Sotiriadis42nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, GreeceImmunology Laboratory, Papageorgiou General Hospital, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, GreeceImmunology Laboratory, Papageorgiou General Hospital, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Nea Eflkarpia, Ring Road Thessalonikis, 56403 Thessaloniki, Greece39 bullous pemphigoid (BP) patients were studied to assess the clinical significance of anti-BP180 and anti-BP230 circulating autoantibodies of BP and correlate their titers with the clinical scores of the BP Disease Area Index (BPDAI) and the Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) as well as with the intensity of pruritus measured by the BPDAI pruritus component. All parameters were evaluated by the time of diagnosis (baseline), month 3, and month 6. Titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with BPDAI component for the intensity of pruritus (, ) at baseline. At month 3, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with the BPDAI component for the intensity of pruritus (, ). At month 6, titers of anti-BP180 autoantibodies were strongly correlated with BPDAI (, ) and ABSIS (, ) values, as well as with the BPDAI component for the intensity of pruritus (, ). There was no statistically significant correlation between titers of anti-BP230 autoantibodies and the BPDAI, ABSIS, and BPDAI component for the intensity of pruritus at the same time points.http://dx.doi.org/10.1155/2012/854795 |
| spellingShingle | Aikaterini Patsatsi Aikaterini Kyriakou Aikaterini Pavlitou-Tsiontsi Anastasia Giannakou Dimitrios Sotiriadis Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid Clinical and Developmental Immunology |
| title | Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid |
| title_full | Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid |
| title_fullStr | Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid |
| title_full_unstemmed | Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid |
| title_short | Association of Autoantibodies to BP180 with Disease Activity in Greek Patients with Bullous Pemphigoid |
| title_sort | association of autoantibodies to bp180 with disease activity in greek patients with bullous pemphigoid |
| url | http://dx.doi.org/10.1155/2012/854795 |
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