Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function

Vascular Contractility Relies on Integrity of Progranulin Pathway: Insights Into Mitochondrial Function

Background The complex interplay between vascular contractility and mitochondrial function is central to cardiovascular disease. The progranulin gene (GRN) encodes glycoprotein PGRN (progranulin), a ubiquitous molecule with known anti‐inflammatory property. However, the role of PGRN in cardiovascula...

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Bibliographic Details
Main Authors: Shubhnita Singh, Ariane Bruder, Rafael M. Costa, Juliano V. Alves, Sivakama Bharathi, Eric S. Goetzman, Thiago Bruder‐Nascimento
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
progranulin
vascular contractility
vasculature
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.037640
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