Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support
Abstract Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which is a complication of critical illness in the ICU; however, there are no reports on the pathogenesis and early predictors of ICU-AW specifically associated with cardiogenic shock (...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-87381-1 |
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| author | Tae Higuchi Tomomi Ide Takeo Fujino Takeshi Tohyama Yuta Nagatomi Tomoyuki Nezu Masataka Ikeda Toru Hashimoto Shouji Matsushima Keisuke Shinohara Masaaki Nishihara Takeshi Iyonaga Tomohiko Akahoshi Tomoki Ushijima Akira Shiose Shintaro Kinugawa Hiroyuki Tsutsui Kohtaro Abe |
| author_facet | Tae Higuchi Tomomi Ide Takeo Fujino Takeshi Tohyama Yuta Nagatomi Tomoyuki Nezu Masataka Ikeda Toru Hashimoto Shouji Matsushima Keisuke Shinohara Masaaki Nishihara Takeshi Iyonaga Tomohiko Akahoshi Tomoki Ushijima Akira Shiose Shintaro Kinugawa Hiroyuki Tsutsui Kohtaro Abe |
| author_sort | Tae Higuchi |
| collection | DOAJ |
| description | Abstract Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which is a complication of critical illness in the ICU; however, there are no reports on the pathogenesis and early predictors of ICU-AW specifically associated with cardiogenic shock (CS). Therefore, this study aimed to investigate the clinical characteristics of ICU-AW in patients with CS requiring mechanical circulatory support (MCS). This study was a single-center, prospective, and observational study. Patients aged 16 years and older who underwent MCS for CS were included. ICU-AW was diagnosed based on Medical Research Council (MRC) score after awakening. The ICU-AW group included patients with the MRC score < 48 points, and the non-ICU-AW group included those with ≥ 48 points. Twenty-eight cases were enrolled on admission and MRC score was evaluated in 23 cases after awakening. Eleven patients were included in the non-ICU-AW group and 12 patients (52%) were in the ICU-AW group. The ICU-AW group showed a higher prevalence of extracorporeal membrane oxygenation and ventilator use. Creatine kinase, troponin T, interleukin (IL)-15 levels on admission were significantly higher, whereas hemoglobin and albumin levels were significantly lower in the ICU-AW group. A strong negative correlation was observed between the initial MRC scores and IL-15 levels. ICU-AW occurred 52% of patients with CS using MCS, indicating the significance of recognizing and managing this complication for those patients. In addition, IL-15 can be a potential biomarker for the early prediction of ICU-AW. |
| format | Article |
| id | doaj-art-0b7b95371e504aa68fdd2f137ae9f7fb |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-0b7b95371e504aa68fdd2f137ae9f7fb2025-02-02T12:19:34ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87381-1Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory supportTae Higuchi0Tomomi Ide1Takeo Fujino2Takeshi Tohyama3Yuta Nagatomi4Tomoyuki Nezu5Masataka Ikeda6Toru Hashimoto7Shouji Matsushima8Keisuke Shinohara9Masaaki Nishihara10Takeshi Iyonaga11Tomohiko Akahoshi12Tomoki Ushijima13Akira Shiose14Shintaro Kinugawa15Hiroyuki Tsutsui16Kohtaro Abe17Department of Rehabilitation Medicine, Kyushu University HospitalDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Rehabilitation Medicine, Kyushu University HospitalDepartment of Rehabilitation Medicine, Kyushu University HospitalDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityEmergency and Critical Care Center, Kyushu University HospitalEmergency and Critical Care Center, Kyushu University HospitalEmergency and Critical Care Center, Kyushu University HospitalDepartment of Cardiovascular Surgery, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Surgery, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityDepartment of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu UniversityAbstract Intensive care unit-acquired weakness (ICU-AW) is recognized as newly-acquired bilateral muscle weakness, which is a complication of critical illness in the ICU; however, there are no reports on the pathogenesis and early predictors of ICU-AW specifically associated with cardiogenic shock (CS). Therefore, this study aimed to investigate the clinical characteristics of ICU-AW in patients with CS requiring mechanical circulatory support (MCS). This study was a single-center, prospective, and observational study. Patients aged 16 years and older who underwent MCS for CS were included. ICU-AW was diagnosed based on Medical Research Council (MRC) score after awakening. The ICU-AW group included patients with the MRC score < 48 points, and the non-ICU-AW group included those with ≥ 48 points. Twenty-eight cases were enrolled on admission and MRC score was evaluated in 23 cases after awakening. Eleven patients were included in the non-ICU-AW group and 12 patients (52%) were in the ICU-AW group. The ICU-AW group showed a higher prevalence of extracorporeal membrane oxygenation and ventilator use. Creatine kinase, troponin T, interleukin (IL)-15 levels on admission were significantly higher, whereas hemoglobin and albumin levels were significantly lower in the ICU-AW group. A strong negative correlation was observed between the initial MRC scores and IL-15 levels. ICU-AW occurred 52% of patients with CS using MCS, indicating the significance of recognizing and managing this complication for those patients. In addition, IL-15 can be a potential biomarker for the early prediction of ICU-AW.https://doi.org/10.1038/s41598-025-87381-1Cardiogenic shockMuscle weaknessRehabilitationBiomarkerInterleukin-15 |
| spellingShingle | Tae Higuchi Tomomi Ide Takeo Fujino Takeshi Tohyama Yuta Nagatomi Tomoyuki Nezu Masataka Ikeda Toru Hashimoto Shouji Matsushima Keisuke Shinohara Masaaki Nishihara Takeshi Iyonaga Tomohiko Akahoshi Tomoki Ushijima Akira Shiose Shintaro Kinugawa Hiroyuki Tsutsui Kohtaro Abe Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support Scientific Reports Cardiogenic shock Muscle weakness Rehabilitation Biomarker Interleukin-15 |
| title | Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| title_full | Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| title_fullStr | Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| title_full_unstemmed | Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| title_short | Clinical characteristics and predictive biomarkers of intensive care unit-acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| title_sort | clinical characteristics and predictive biomarkers of intensive care unit acquired weakness in patients with cardiogenic shock requiring mechanical circulatory support |
| topic | Cardiogenic shock Muscle weakness Rehabilitation Biomarker Interleukin-15 |
| url | https://doi.org/10.1038/s41598-025-87381-1 |
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