Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury
Summary: Skilled forelimb patterning is regulated by the corticospinal tract (CST) with support from brainstem regions. When the CST is lesioned, there is a loss of forelimb function; however, if indirect pathways remain intact, rehabilitative training can facilitate recovery. Following spinal cord...
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Elsevier
2024-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224025963 |
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| author | Imran S. Sheikh Kathleen M. Keefe Noelle A. Sterling Ian P. Junker Chen Li Jie Chen Xiao-Ming Xu Lynn G. Kirby George M. Smith |
| author_facet | Imran S. Sheikh Kathleen M. Keefe Noelle A. Sterling Ian P. Junker Chen Li Jie Chen Xiao-Ming Xu Lynn G. Kirby George M. Smith |
| author_sort | Imran S. Sheikh |
| collection | DOAJ |
| description | Summary: Skilled forelimb patterning is regulated by the corticospinal tract (CST) with support from brainstem regions. When the CST is lesioned, there is a loss of forelimb function; however, if indirect pathways remain intact, rehabilitative training can facilitate recovery. Following spinal cord injury, rehabilitation is thought to enhance the reorganization and plasticity of spared supraspinal-propriospinal circuits, aiding functional recovery. This study focused on the roles of cervical propriospinal interneurons (PNs) and rubrospinal neurons (RNs) in the recovery of reaching and grasping behaviors in rats with bilateral lesions of the CST and dorsal columns at C5. The lesions resulted in a 50% decrease in pellet retrieval, which normalized over four weeks of training. Silencing PNs or RNs after recovery resulted in reduced retrieval success. Notably, silencing both pathways corresponded to greater functional loss, underscoring their parallel contributions to recovery, alongside evidence of CST fiber sprouting in the spinal cord and red nucleus. |
| format | Article |
| id | doaj-art-0b70d7ce4e8b45c0a2f083bd2ec1ac7b |
| institution | OA Journals |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-0b70d7ce4e8b45c0a2f083bd2ec1ac7b2025-08-20T01:59:40ZengElsevieriScience2589-00422024-12-01271211137110.1016/j.isci.2024.111371Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injuryImran S. Sheikh0Kathleen M. Keefe1Noelle A. Sterling2Ian P. Junker3Chen Li4Jie Chen5Xiao-Ming Xu6Lynn G. Kirby7George M. Smith8Department of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Anatomy and Cell Biology, Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USASpinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USADepartment of Anatomy and Cell Biology, Center for Substance Abuse Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USADepartment of Neuroscience, Shriners Hospitals Pediatric Research Center, Center for Neural Rehabilitation and Repair, Lewis Katz School of Medicine at Temple University, Philadelphia, PA 19140, USA; Corresponding authorSummary: Skilled forelimb patterning is regulated by the corticospinal tract (CST) with support from brainstem regions. When the CST is lesioned, there is a loss of forelimb function; however, if indirect pathways remain intact, rehabilitative training can facilitate recovery. Following spinal cord injury, rehabilitation is thought to enhance the reorganization and plasticity of spared supraspinal-propriospinal circuits, aiding functional recovery. This study focused on the roles of cervical propriospinal interneurons (PNs) and rubrospinal neurons (RNs) in the recovery of reaching and grasping behaviors in rats with bilateral lesions of the CST and dorsal columns at C5. The lesions resulted in a 50% decrease in pellet retrieval, which normalized over four weeks of training. Silencing PNs or RNs after recovery resulted in reduced retrieval success. Notably, silencing both pathways corresponded to greater functional loss, underscoring their parallel contributions to recovery, alongside evidence of CST fiber sprouting in the spinal cord and red nucleus.http://www.sciencedirect.com/science/article/pii/S2589004224025963Natural sciencesBiological sciencesNeuroscienceSystems neuroscience |
| spellingShingle | Imran S. Sheikh Kathleen M. Keefe Noelle A. Sterling Ian P. Junker Chen Li Jie Chen Xiao-Ming Xu Lynn G. Kirby George M. Smith Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury iScience Natural sciences Biological sciences Neuroscience Systems neuroscience |
| title | Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| title_full | Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| title_fullStr | Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| title_full_unstemmed | Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| title_short | Compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| title_sort | compensatory adaptation of parallel motor pathways promotes skilled forelimb recovery after spinal cord injury |
| topic | Natural sciences Biological sciences Neuroscience Systems neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224025963 |
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