A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices
A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/896143 |
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| author | Ashley P. Barlow Jane He Cindy Tian Peter Jeffery Stephen C. Mason Bao-Jun Tai Han Jiang Gareth D. Rees Min Quan Du |
| author_facet | Ashley P. Barlow Jane He Cindy Tian Peter Jeffery Stephen C. Mason Bao-Jun Tai Han Jiang Gareth D. Rees Min Quan Du |
| author_sort | Ashley P. Barlow |
| collection | DOAJ |
| description | A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3 and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects (N=110), stratified into two groups (N=55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P<0.0001). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P≤0.0059, Dentifrice A; P≤0.0137, Dentifrice B). |
| format | Article |
| id | doaj-art-0b67c35522144780a0c2c55b9c62eb03 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-0b67c35522144780a0c2c55b9c62eb032025-02-03T07:26:18ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/896143896143A Comparative Evaluation of the Efficacy of Two Novel Desensitising DentifricesAshley P. Barlow0Jane He1Cindy Tian2Peter Jeffery3Stephen C. Mason4Bao-Jun Tai5Han Jiang6Gareth D. Rees7Min Quan Du8GlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UKSino-American Tianjin SmithKline and French Laboratories Ltd., Beijing, ChinaSino-American Tianjin SmithKline and French Laboratories Ltd., Beijing, ChinaGlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UKGlaxoSmithKline Consumer Healthcare, Surrey Weybridge, KT13 0DE, UKKey Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, LuoYu Road 237, Wuhan 430070, ChinaKey Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, LuoYu Road 237, Wuhan 430070, ChinaGenesis Oral Bioscience, Consultancy & Scientific Writing, Regents Mews, Surrey, Horley RH6 7AN, UKKey Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, LuoYu Road 237, Wuhan 430070, ChinaA comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3 and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP. Subjects (N=110), stratified into two groups (N=55), brushed twice-daily for 60 s, over an 8-week period. Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks. A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level. After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P<0.0001). Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P≤0.0059, Dentifrice A; P≤0.0137, Dentifrice B).http://dx.doi.org/10.1155/2012/896143 |
| spellingShingle | Ashley P. Barlow Jane He Cindy Tian Peter Jeffery Stephen C. Mason Bao-Jun Tai Han Jiang Gareth D. Rees Min Quan Du A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices International Journal of Dentistry |
| title | A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices |
| title_full | A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices |
| title_fullStr | A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices |
| title_full_unstemmed | A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices |
| title_short | A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices |
| title_sort | comparative evaluation of the efficacy of two novel desensitising dentifrices |
| url | http://dx.doi.org/10.1155/2012/896143 |
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