Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate
With the increasing clinical demand for orthopedic implants, bone tissue engineering based on a variety of bioactive materials has shown promising applications in bone repair. And various physiological cues, such as mechanical, electrical, and magnetic stimulation, can influence cell fate and partic...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X25000014 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087451635548160 |
|---|---|
| author | Huagui Huang Kaizhong Wang Xiangyan Liu Xin Liu Jinzuo Wang Moran Suo Hui Wang Shuang Chen Xin Chen Zhonghai Li |
| author_facet | Huagui Huang Kaizhong Wang Xiangyan Liu Xin Liu Jinzuo Wang Moran Suo Hui Wang Shuang Chen Xin Chen Zhonghai Li |
| author_sort | Huagui Huang |
| collection | DOAJ |
| description | With the increasing clinical demand for orthopedic implants, bone tissue engineering based on a variety of bioactive materials has shown promising applications in bone repair. And various physiological cues, such as mechanical, electrical, and magnetic stimulation, can influence cell fate and participate in bone regeneration. Natural bone has a piezoelectric effect due to the non-centrosymmetric nature of collagen, which can aid in cell adhesion, proliferation and differentiation, and bone growth by converting mechanical stimuli into electrical stimuli. Piezoelectric materials have the same piezoelectric effect as human bone, and they are able to deform in response to physiological movement, thus providing electrical stimulation to cells or damaged tissue without the need for an external power source. Among them, Barium titanate (BaTiO3) is widely used in tumor therapy, tissue engineering, health detection and drug delivery because of its good biocompatibility, low cytotoxicity and good piezoelectric properties. This review describes the piezoelectric effect of natural bone and the characteristics of various types of piezoelectric materials, from the synthesis and physicochemical characteristics of BaTiO3 and its application in biomedicine. And it highlights the great potential of BaTiO3 as piezoelectric biomaterials in the field of bone tissue engineering in anticipation of providing new ideas and opportunities for researchers.The translational potential of this article: This review systematically discusses barium titanate, a bioactive material that can mimic the piezoelectric effect of natural bone tissue, which can intervene in the regenerative repair of bone by providing a sustained electrical microenvironment for bone repair scaffolds. This may help to solve the current problem of poor osteogenic properties of bioactive materials by utilizing barium titanate. |
| format | Article |
| id | doaj-art-0b58786ac9f141bead6d81bdccdc422b |
| institution | Kabale University |
| issn | 2214-031X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj-art-0b58786ac9f141bead6d81bdccdc422b2025-02-06T05:11:45ZengElsevierJournal of Orthopaedic Translation2214-031X2025-03-015194107Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanateHuagui Huang0Kaizhong Wang1Xiangyan Liu2Xin Liu3Jinzuo Wang4Moran Suo5Hui Wang6Shuang Chen7Xin Chen8Zhonghai Li9Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaDepartment of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, China; Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China; Corresponding author. Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.Department of Orthopedics, First Affiliated Hospital of Dalian Medical University, Dalian, China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopedic Diseases, Liaoning Province, China; Corresponding author. Dept. Orthopedics, the First Affiliated Hospital of Dalian Medical University, No. 5, Longbin Road, Dalian Development Zone, Dalian, Liaoning Province, China.With the increasing clinical demand for orthopedic implants, bone tissue engineering based on a variety of bioactive materials has shown promising applications in bone repair. And various physiological cues, such as mechanical, electrical, and magnetic stimulation, can influence cell fate and participate in bone regeneration. Natural bone has a piezoelectric effect due to the non-centrosymmetric nature of collagen, which can aid in cell adhesion, proliferation and differentiation, and bone growth by converting mechanical stimuli into electrical stimuli. Piezoelectric materials have the same piezoelectric effect as human bone, and they are able to deform in response to physiological movement, thus providing electrical stimulation to cells or damaged tissue without the need for an external power source. Among them, Barium titanate (BaTiO3) is widely used in tumor therapy, tissue engineering, health detection and drug delivery because of its good biocompatibility, low cytotoxicity and good piezoelectric properties. This review describes the piezoelectric effect of natural bone and the characteristics of various types of piezoelectric materials, from the synthesis and physicochemical characteristics of BaTiO3 and its application in biomedicine. And it highlights the great potential of BaTiO3 as piezoelectric biomaterials in the field of bone tissue engineering in anticipation of providing new ideas and opportunities for researchers.The translational potential of this article: This review systematically discusses barium titanate, a bioactive material that can mimic the piezoelectric effect of natural bone tissue, which can intervene in the regenerative repair of bone by providing a sustained electrical microenvironment for bone repair scaffolds. This may help to solve the current problem of poor osteogenic properties of bioactive materials by utilizing barium titanate.http://www.sciencedirect.com/science/article/pii/S2214031X25000014Barium titanateBone repairElectrical stimulationPiezoelectricityTissue engineering |
| spellingShingle | Huagui Huang Kaizhong Wang Xiangyan Liu Xin Liu Jinzuo Wang Moran Suo Hui Wang Shuang Chen Xin Chen Zhonghai Li Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate Journal of Orthopaedic Translation Barium titanate Bone repair Electrical stimulation Piezoelectricity Tissue engineering |
| title | Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate |
| title_full | Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate |
| title_fullStr | Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate |
| title_full_unstemmed | Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate |
| title_short | Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate |
| title_sort | piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering barium titanate |
| topic | Barium titanate Bone repair Electrical stimulation Piezoelectricity Tissue engineering |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X25000014 |
| work_keys_str_mv | AT huaguihuang piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT kaizhongwang piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT xiangyanliu piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT xinliu piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT jinzuowang piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT moransuo piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT huiwang piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT shuangchen piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT xinchen piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate AT zhonghaili piezoelectricbiomaterialsforprovidingelectricalstimulationinbonetissueengineeringbariumtitanate |