Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway

Silencing of SCEL promotes progression of oral squamous cell carcinoma via activating TGF-β/Smad pathway

Abstract Objective SCEL serves as a precursor protein for the cornified envelope (CE), and its abnormal expression has been identified in various malignancies. Despite this, the functional role and detailed mechanisms of SCEL in oral squamous cell carcinoma (OSCC) remain to be clarified. Methods mRN...

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Bibliographic Details
Main Authors: Danping Li, Limei Li, Shu Wu, Jun Zhao, Haishan Zhang, Qiaoli Chen, Yingxi Mo, Liudmila Matskova, Ping Li, Xiaoying Zhou
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Oncology
Subjects:
Oral squamous cell carcinoma
SCEL
TGF-β signaling pathway
Differentiation
Metastasis
MiR-5696
Online Access:https://doi.org/10.1007/s12672-025-02423-4
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