ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction

ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction

Abstract Myocardial infarction (MI) compromises the cardiac microvascular endothelial barrier, increasing leakage and inflammation. HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. Here, we show that inducible, adult endo...

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Main Authors: Karim Ullah, Lizhuo Ai, Yan Li, Lifeng Liu, Qin Zhang, Kaichao Pan, Zainab Humayun, Lin Piao, Albert Sitikov, Qiong Zhao, Qiaozhu Su, Willard Sharp, Yun Fang, David Wu, James K. Liao, Rongxue Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07753-1
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