Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis
Abstract This investigation aimed to develop a radiographic 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis (JIA), and to perform a validation against expert evaluations. Data were collected from a population-based Nordic JIA cohort of...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86410-3 |
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| author | Stratos Vassis Mia Glerup Ida Tambjerg Annelise Küseler Cory M. Resnick Carlalberta Verna Troels Herlin Lillemor Berntson Charlotte Myrup Ellen Nordal Marite Rygg Kristiina Aalto Sven Erik Noerholt Thomas K. Pedersen Peter Stoustrup |
| author_facet | Stratos Vassis Mia Glerup Ida Tambjerg Annelise Küseler Cory M. Resnick Carlalberta Verna Troels Herlin Lillemor Berntson Charlotte Myrup Ellen Nordal Marite Rygg Kristiina Aalto Sven Erik Noerholt Thomas K. Pedersen Peter Stoustrup |
| author_sort | Stratos Vassis |
| collection | DOAJ |
| description | Abstract This investigation aimed to develop a radiographic 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis (JIA), and to perform a validation against expert evaluations. Data were collected from a population-based Nordic JIA cohort of 240 patients that received a cone-beam computed tomography (CBCT) scan approximately 17 years after onset of JIA. The cohort was randomized into two groups: A baseline group for establishing the index (n = 210) and a test group (n = 30). The standardized index generation process led to the inclusion of six radiographic outcome measures, each representing different facets of dentofacial deformities. Specific severity scores were established for three domains; dentofacial asymmetry (0–8), vertical deviation (0–8), and sagittal deviation (0–8). An overall dentofacial deformity index score was computed by aggregating the scores from the six variables, with the total score ranging from 0 to 24. The validity of the index was assessed by comparing the index score with expert evaluations. Based on the generated index, 10 patients exhibited severe deformities. Reliable agreement between data-generated index scores and expert assessments was found. A 3D radiographic dentofacial deformity index was generated and tested. This index can support an objective assessment of the severity of dentofacial deformities related to JIA in a clinical setting and future research. |
| format | Article |
| id | doaj-art-0b2ce8bea6a04285a271c1a56249af67 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0b2ce8bea6a04285a271c1a56249af672025-01-26T12:24:07ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-86410-3Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritisStratos Vassis0Mia Glerup1Ida Tambjerg2Annelise Küseler3Cory M. Resnick4Carlalberta Verna5Troels Herlin6Lillemor Berntson7Charlotte Myrup8Ellen Nordal9Marite Rygg10Kristiina Aalto11Sven Erik Noerholt12Thomas K. Pedersen13Peter Stoustrup14Section of Orthodontics, Department of Dentistry and Oral Health, Aarhus UniversityDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Institute of Clinical Medicine, Aarhus UniversitySection of Orthodontics, Department of Dentistry and Oral Health, Aarhus UniversitySection of Orthodontics, Department of Dentistry and Oral Health, Aarhus UniversityHarvard Medical School and Harvard School of Dental Medicine; Department of Oral and Maxillofacial Surgery, Boston Children’s HospitalDepartment of Paediatric Oral Health and Orthodontics, University Center of Dental Medicine UZB, University of BaselDepartment of Pediatrics and Adolescent Medicine, Aarhus University Hospital, Institute of Clinical Medicine, Aarhus UniversityDepartment of Women’s and Children’s Health, Uppsala UniversityDepartment of Pediatrics, Copenhagen University Hospital RigshospitaletDepartment of Pediatrics, University Hospital of North NorwayDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU)Department of Pediatrics, New Children’s Hospital, Helsinki University Hospital, University of Helsinki and Pediatric Research CenterDepartment of Oral and Maxillofacial Surgery, Aarhus University HospitalSection of Orthodontics, Department of Dentistry and Oral Health, Aarhus UniversitySection of Orthodontics, Department of Dentistry and Oral Health, Aarhus UniversityAbstract This investigation aimed to develop a radiographic 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis (JIA), and to perform a validation against expert evaluations. Data were collected from a population-based Nordic JIA cohort of 240 patients that received a cone-beam computed tomography (CBCT) scan approximately 17 years after onset of JIA. The cohort was randomized into two groups: A baseline group for establishing the index (n = 210) and a test group (n = 30). The standardized index generation process led to the inclusion of six radiographic outcome measures, each representing different facets of dentofacial deformities. Specific severity scores were established for three domains; dentofacial asymmetry (0–8), vertical deviation (0–8), and sagittal deviation (0–8). An overall dentofacial deformity index score was computed by aggregating the scores from the six variables, with the total score ranging from 0 to 24. The validity of the index was assessed by comparing the index score with expert evaluations. Based on the generated index, 10 patients exhibited severe deformities. Reliable agreement between data-generated index scores and expert assessments was found. A 3D radiographic dentofacial deformity index was generated and tested. This index can support an objective assessment of the severity of dentofacial deformities related to JIA in a clinical setting and future research.https://doi.org/10.1038/s41598-025-86410-3 |
| spellingShingle | Stratos Vassis Mia Glerup Ida Tambjerg Annelise Küseler Cory M. Resnick Carlalberta Verna Troels Herlin Lillemor Berntson Charlotte Myrup Ellen Nordal Marite Rygg Kristiina Aalto Sven Erik Noerholt Thomas K. Pedersen Peter Stoustrup Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis Scientific Reports |
| title | Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| title_full | Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| title_fullStr | Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| title_full_unstemmed | Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| title_short | Development of a 3D cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| title_sort | development of a 3d cephalometric index to grade severity of dentofacial deformity in patients with juvenile idiopathic arthritis |
| url | https://doi.org/10.1038/s41598-025-86410-3 |
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